What is the most important approach in current drug discovery: doing the right things or doing things right?

Drug Discovery Today
Thomas ElebringAlleyn T Plowright

Abstract

Doing the right things or doing things right: what is the most important focus for current drug discovery to secure delivery of new drugs of sustainable value to patients, healthcare professionals and healthcare providers? Some of the challenges faced today in drug discovery are addressed here: the relationship between R&D speed, cost and quality; how selection of performance metrics can affect the quality of the R&D output; the importance of leadership and management; how process orientation can affect, for example, creativity and innovation; the importance of selecting the right pharmacologic target and the right chemical lead; and why the use of drug-target kinetic and thermodynamic data to drive lead selection and lead optimization could increase success rates.

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Citations

May 30, 2014·Chemical Reviews·Aiying GuanMark Dekeyser
Mar 22, 2014·Future Medicinal Chemistry·John G CummingMichael J Waring
Sep 17, 2015·Drug Discovery Today·Serge MignaniJean-Pierre Majoral
Jan 24, 2016·Drug Discovery Today·Serge MignaniJean-Pierre Majoral
Sep 6, 2013·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Michiel B Vandegehuchte, Colin R Janssen
Nov 21, 2017·Chemical Society Reviews·Serge MignaniJean-Pierre Majoral
Nov 13, 2019··Shintaro SengokuTakeshi Akiyama

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