What is the most relevant standard of success in assisted reproduction? The next step to improving outcomes of IVF: consider the whole treatment

Human Reproduction
E M E W HeijnenBart C J M Fauser

Abstract

Changing the way in which successful IVF treatment is defined offers a tool to improve efficacy while reducing costs and complications of treatment. Crucial to this paradigm shift is the move away from considering outcomes in terms of the single IVF cycle, and towards the started IVF treatment as a whole. We propose the most informative end-point of success in IVF to be the term singleton birth rate per started IVF treatment (or per given time period) in the overall context of patient discomfort, complications and costs. These end-points are important not only for patients, but also for clinicians, health economists and policy makers. Such an approach would encourage the development of patient-friendly and cheaper stimulation protocols with less stress, discomfort and side effects. The combination of mild ovarian stimulation with single embryo transfer may provide the same overall pregnancy rate per total IVF treatment, achieved in the same amount of time for similar direct costs, but with reduced patient stress and discomfort, and the near complete elimination of multiple pregnancies. This would offer major health and indirect cost benefits. If IVF success rates were to be expressed in terms of delivery of a term single baby p...Continue Reading

Citations

May 2, 2012·Archives of Gynecology and Obstetrics·Charalampos SiristatidisDimitrios Kassanos
May 25, 2005·Lancet·Bart C J M FauserNick S Macklon
Feb 1, 2013·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Lee E Hullender RubinDeborah L Ackerman
Jun 12, 2008·Human Reproduction·M F G VerbergN S Macklon
Nov 4, 2011·Human Reproduction·Deborah PayneGuy Gudex
Oct 26, 2012·Human Reproduction·L GianaroliR Lobo
Apr 22, 2009·Human Reproduction Update·P DevroeyUNKNOWN Evian Annual Reproduction (EVAR) Workshop Group 2008
Mar 6, 2013·Human Reproduction Update·UNKNOWN ESHRE Capri Workshop Group
Sep 10, 2011·Gynécologie, obstétrique & fertilité·R Cabry-GoubetP Merviel
Oct 5, 2010·Gynécologie, obstétrique & fertilité·R Cabry-GoubetP Merviel
Jul 27, 2010·Fertility and Sterility·Jacques P StassartWilliam R Phipps
Jun 24, 2010·Reproductive Biomedicine Online·Hesham G Al-Inany, Pieter van Gelder
Jun 21, 2007·Reproductive Biomedicine Online·F UbaldiE Greco
Aug 30, 2008·Fertility and Sterility·Sharon E MoayeriAlan M Garber
Sep 3, 2008·Placenta·F Ubaldi, L Rienzi
Mar 8, 2008·Fertility and Sterility·Pasquale Patrizio, Denny Sakkas
Oct 20, 2006·Best Practice & Research. Clinical Obstetrics & Gynaecology·B C Tarlatzis, E M Kolibianakis
Nov 1, 2006·Best Practice & Research. Clinical Obstetrics & Gynaecology·M F G VerbergB C J M Fauser
Nov 7, 2006·Best Practice & Research. Clinical Obstetrics & Gynaecology·G M Warnes, R J Norman
Jul 14, 2010·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Georgina M ChambersMichael G Chapman
Sep 9, 2006·Gynécologie, obstétrique & fertilité·L Larue, J-L Pouly
Oct 30, 2012·Fertility and Sterility·Luca GianaroliRoger A Lobo
Aug 22, 2016·Journal of Assisted Reproduction and Genetics·John B WhitneyRobert E Anderson
Sep 25, 2016·Human Reproduction·Jack WilkinsonAndy Vail
Jul 17, 2007·Human Reproduction Update·UNKNOWN ESHRE Capri Workshop Group
Jan 17, 2019·Human Reproduction·H L TorranceB W J Mol
Jan 26, 2006·Endocrine Reviews·Nick S MacklonBart C J M Fauser
Feb 14, 2020·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Hayden Anthony Homer
Jun 23, 2007·Human Reproduction·Guido Pennings, Willem Ombelet
Jan 4, 2018·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M A GadallaB W J Mol
Dec 25, 2004·Human Reproduction Update·Pedro N Barri
Oct 31, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ramón AurellPedro N Barri
Oct 19, 2020·Fertility and Sterility·May-Tal Sauerbrun-CutlerGary N Frishman
Jan 22, 2021·Diagnostic and Prognostic Research·Jack WilkinsonStephen A Roberts

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.