PMID: 9436721Jan 22, 1998Paper

What is the optimal dose of botulinum toxin A in the treatment of cervical dystonia? Results of a double blind, placebo controlled, dose ranging study using Dysport. German Dystonia Study Group

Journal of Neurology, Neurosurgery, and Psychiatry
W PoeweG Künig

Abstract

Botulinum toxin injections have become a first line therapeutic approach in cervical dystonia. Nevertheless, published dosing schedules, responder rates, and frequency of adverse events vary widely. The present prospective multicentre placebo controlled double blind dose ranging study was performed in a homogenous group of previously untreated patients with rotational torticollis to obtain objective data on dose-response relations. Seventy five patients were randomly assigned to receive treatment with placebo or total doses of 250, 500, and 1000 Dysport units divided between one splenius capitis (0, 175, 350, 700 units) and the contralateral sternocleidomastoid (0, 75, 150, 300 units) muscle. Assessments were obtained at baseline and weeks 2, 4, and 8 after treatment and comprised a modified Tsui scale, a four point pain scale, a checklist of adverse events, global assessment of improvement, and a global rating taking into account efficacy and adverse events. At week 8 the need for retreatment was assessed and then the code was unblinded. For those still responding, there was an open follow up until retreatment to assess the duration of effect. Seventy nine per cent reported subjective improvement at one or more follow up visit...Continue Reading

References

Sep 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·A P Moore, L D Blumhardt
Jan 1, 1991·Movement Disorders : Official Journal of the Movement Disorder Society·I T LorentzC Yiannikas
Aug 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·J JankovicD T Donovan
Aug 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·J D Blackie, A J Lees
Feb 1, 1990·Neurology·J Jankovic, K Schwartz
Jan 1, 1988·Movement Disorders : Official Journal of the Movement Disorder Society·J G NuttL J Melton
Jan 1, 1988·Advances in Neurology·J K TsuiD B Calne
Jan 1, 1987·Movement Disorders : Official Journal of the Movement Disorder Society·M F BrinR E Lovelace
Jan 1, 1994·Movement Disorders : Official Journal of the Movement Disorder Society·G E BorodicK Smith

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Citations

Aug 1, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·P KrackW Poewe
Nov 13, 2007·Journal of Neural Transmission·C L Comella
Mar 26, 2009·Journal of Neural Transmission·Bahram MohammadiReinhard Dengler
Mar 20, 2002·Current Neurology and Neuroscience Reports·R Tintner, J Jankovic
Jun 23, 2010·Current Neurology and Neuroscience Reports·Virgilio Gerald H Evidente, Charles H Adler
Jun 5, 2012·Current Neurology and Neuroscience Reports·Mary Ann Thenganatt, Stanley Fahn
Nov 30, 2000·Current Treatment Options in Neurology·M F Brin, R Benabou
Dec 2, 2008·Nature Clinical Practice. Neurology·Bahman Jabbari
Sep 12, 2008·The Neurologist·Allison Brashear
Jan 19, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C L Comella, P D Thompson
Jul 17, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·I NovakUNKNOWN Cerebral Palsy Institute
Apr 20, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·J MüllerW Poewe
Feb 1, 2010·Continuum : Lifelong Learning in Neurology·David Charles, Chandler E Gill
Nov 16, 2001·Drugs·M VelickovicM F Brin
Jun 15, 2011·Drugs·Susan J KeamEmma D Deeks
May 14, 2010·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Andy Pickett
Aug 19, 2011·Annals of Indian Academy of Neurology·Afshan JabeenRupam Borgohain
Oct 22, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Mary Ann Thenganatt, Joseph Jankovic
Nov 21, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Syrus Karsai, Christian Raulin
Jun 26, 2015·Toxins·Carlos Henrique Ferreira CamargoHélio Afonso Ghizoni Teive
Mar 30, 2005·Expert Opinion on Drug Safety·Allison Brashear
Oct 1, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Bahman Jabbari, Duarte Machado
Feb 9, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Jörg MüllerWerner Poewe
Jun 30, 2015·Neurologia Medico-chirurgica·Takashi AsahiSatoshi Kuroda
Jul 19, 2008·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Cem KurtogluHakan Uysal
Sep 11, 2007·Clinical Therapeutics·Mary Ann ChapmanP David Charles
Nov 23, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M NaumannM Relja
Apr 17, 2015·Journal of Neurology·Alberto AlbaneseCharalampos Tzoulis
Mar 13, 2009·Neurological Research·B MohammadiK Kollewe
Dec 6, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Ji Young YunBeom S Jeon
Feb 15, 2012·The International Journal of Neuroscience·Francisco Vivancos-MatellanoExuperio Diez-Tejedor
Jun 20, 2015·Journal of the Neurological Sciences·Josef FinstererDaniel Truong
Jan 25, 2005·Autonomic Neuroscience : Basic & Clinical·Tanja SchlerethFrank Birklein
Oct 14, 2016·Frontiers in Neurology·Maria Fiorella ContarinoMarina A J Tijssen
Jul 8, 2008·Neurologic Clinics·Eric MolhoMark Lew

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