What is the optimal dose of epinephrine during cardiopulmonary resuscitation in a rat model?

The American Journal of Emergency Medicine
Meng-Hua ChenFengqing Song

Abstract

Because different species may require different doses of drug to produce the same physiologic response, we were provoked to evaluate the dose-response of epinephrine during cardiopulmonary resuscitation (CPR) and identify what is the optimal dose of epinephrine in a rat cardiac arrest model. Rat cardiac arrest was induced via asphyxia, and then the effects of different doses of epinephrine (0.04, 0.2, and 0.4 mg/kg IV, respectively) and saline on the outcome of CPR were compared (n = 10/each group). The primary outcome measure was restoration of spontaneous circulation (ROSC), and the secondary was the change of spontaneous respiration and hemodynamics after ROSC. Rates of ROSC were 9 of 10, 8 of 10, 7 of 10, and 1 of 10 in the low-dose, medium-dose, and high-dose epinephrine groups and saline group, respectively. The rates of withdrawal from the ventilator within 60 minutes in the low-dose (7 of 9) and medium-dose epinephrine groups (7 of 8) were higher than in the high-dose epinephrine group (1 of 7, P < .05). Mean arterial pressures were comparable, but the heart rate in the high-dose epinephrine group was the lowest among epinephrine groups after ROSC. These differences in part of time points reached statistical significanc...Continue Reading

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Citations

Feb 16, 2013·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Stephanie CarreiroJason B Hack
Aug 1, 2014·Critical Care : the Official Journal of the Critical Care Forum·Pongsakorn AtiksawedparitAmmarin Thakkinstian
Aug 3, 2012·Journal of Veterinary Emergency and Critical Care·Elizabeth A RozanskiRECOVER Advanced Life Support Domain Worksheet Authors
Dec 3, 2014·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Caspar W KrammerJens A Sørensen
May 17, 2019·Open Life Sciences·Svitlana Shkurashivska, Hanna Ersteniuk

Related Concepts

Medihaler-Epi
Basic Cardiac Life Support
Rats, Holtzman
Spearman Rank Correlation Coefficient
Asphyxia
Blood Circulation
Cardiopulmonary Resuscitation
Epinephrine
Heart
Cardiac Arrest

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