What Is the Optimum Timing of Postmastectomy Radiotherapy in Two-Stage Prosthetic Reconstruction: Radiation to the Tissue Expander or Permanent Implant?

Plastic and Reconstructive Surgery
Peter G CordeiroEvan Matros

Abstract

Postmastectomy radiotherapy is increasingly common for patients with advanced breast cancer. The optimal timing and sequence of mastectomy, reconstruction, and radiotherapy remains unresolved for patients choosing immediate two-stage prosthetic reconstruction. Long-term outcomes were compared for all patients with prosthetic-based reconstruction without radiation, radiation to the tissue expander, or to the permanent implant from 2003 to 2012 performed by the senior author (P.G.C.). Surgeon-evaluated outcomes included reconstructive failure, aesthetic results, and capsular contracture. Odds of failure with radiotherapy at different times were evaluated with logistic regression and Kaplan-Meier analysis. Patient-reported outcomes were assessed using the BREAST-Q. A total of 1486 reconstructions without radiation, 94 reconstructions with tissue expander radiation, and 210 reconstructions with permanent implant radiation were included. Six-year predicted failure rates were greater for patients with tissue expander radiation than for patients with permanent implant radiation (32 percent versus 16.4 percent; p < 0.01). Patients undergoing radiation to the tissue expander had a greater proportion of very good to excellent aesthetic r...Continue Reading

References

Oct 2, 1997·The New England Journal of Medicine·J RagazI A Olivotto
Apr 29, 2004·Plastic and Reconstructive Surgery·Steven J KronowitzGeoffrey L Robb
Aug 1, 2009·Plastic and Reconstructive Surgery·Andrea L PusicStefan J Cano
Jul 27, 2011·Plastic and Reconstructive Surgery·Maurizio B NavaGiuseppe Catanuto
Dec 29, 2012·Plastic and Reconstructive Surgery·Claudia R AlbornozEvan Matros
Nov 10, 2013·Annals of Surgical Oncology·Colleen M McCarthyAndrea L Pusic
Aug 28, 2014·Plastic and Reconstructive Surgery·Claudia R AlbornozEvan Matros

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Citations

Mar 5, 2016·Annals of Surgical Oncology·Utku C DolenTerence M Myckatyn
Mar 30, 2017·Plastic and Reconstructive Surgery·Joseph J Disa, Evan Matros
Apr 19, 2017·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Bassim El-SabawiKetan M Patel
May 26, 2017·Plastic and Reconstructive Surgery·Horatiu MuresanDaniel J Ceradini
Aug 24, 2017·Plastic and Reconstructive Surgery. Global Open·Lynne N BettingerDaniel I Jacobs
Feb 6, 2018·Journal of Clinical Nursing·Carmen Cereijo-GareaVanesa Balboa-Barreiro
Feb 27, 2018·Annals of Plastic Surgery·Alexandra J LinJason A Spector
Nov 23, 2017·Plastic and Reconstructive Surgery·Allen Gabriel, G Patrick Maxwell
Apr 11, 2018·Plastic and Reconstructive Surgery. Global Open·Steven SigaloveAllen Gabriel
Jan 18, 2018·Polski przeglad chirurgiczny·Agnieszka KolacinskaMaciej Berkan
Jan 30, 2018·BioMed Research International·Elisa BelliniEdoardo Raposio
Feb 16, 2016·Journal of Surgical Oncology·Hana FarhangkhoeeJoseph Disa
Jun 28, 2019·Plastic and Reconstructive Surgery·Jordan D FreyNolan S Karp
Dec 23, 2017·Aesthetic Plastic Surgery·Cemile Nurdan OzturkRisal Djohan
Nov 26, 2019·Plastic and Reconstructive Surgery·Jonas A NelsonAndrea L Pusic
Jun 1, 2017·American Society of Clinical Oncology Educational Book·Henry M KuererRobert W Mutter
Jan 28, 2020·Plastic and Reconstructive Surgery·Amy S Colwell, Erin M Taylor
Sep 28, 2016·Plastic and Reconstructive Surgery·Katherine B SantosaEdwin G Wilkins
Jan 26, 2018·Plastic and Reconstructive Surgery·Clifford C SheckterEvan Matros
Jan 10, 2020·Plastic and Reconstructive Surgery·Adeyiza O MomohReshma Jagsi
Nov 9, 2019·Journal of Plastic Surgery and Hand Surgery·Emma HanssonLars Sandman
May 23, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dean A ShumwayReshma Jagsi
Jan 12, 2016·Journal of Surgical Oncology·Bassim El-SabawiKetan M Patel
Jan 29, 2019·Plastic and Reconstructive Surgery·Jordan D FreyMihye Choi
Aug 19, 2016·Plastic and Reconstructive Surgery. Global Open·Thomas LamJohn Boyages
Sep 9, 2015·Journal of Surgical Oncology·Bassim El-SabawiKetan M Patel
Feb 25, 2017·Plastic and Reconstructive Surgery·Troy A PittmanScott L Spear
Jan 17, 2020·Plastic and Reconstructive Surgery. Global Open·Kristina M CrawfordMatthew R Endara

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