What is the potential increase in the heart graft pool by cardiac donation after circulatory death?

Transplant International : Official Journal of the European Society for Organ Transplantation
T NoterdaemeJean-Olivier Defraigne

Abstract

Heart transplantation remains the only definite treatment option for end-stage heart diseases. The use of hearts procured after donation after circulatory death (DCD) could help decrease the heart graft shortage. The aim of this study was to evaluate the potential increase in heart graft pool by developing DCD heart transplantation. We retrospectively reviewed our local donor database from 2006 to 2011, and screened the complete controlled DCD donor population for potential heart donors, using the same criteria as for donation after brain death (DBD) heart transplantation. Acceptable donation warm ischemic time (DWIT) was limited to 30 min. During this period 177 DBD and 70 DCD were performed. From the 177 DBD, a total of 70 (39.5%) hearts were procured and transplanted. Of the 70 DCD, eight (11%) donors fulfilled the criteria for heart procurement with a DWIT of under 30 min. Within the same period, 82 patients were newly listed for heart transplantation, of which 53 were transplanted, 20 died or were unlisted, and 9 were waiting. It could be estimated that 11% of the DCD might be heart donors, representing a 15% increase in heart transplant activity, as well as potential reduction in the deaths on the waiting list by 40%.

References

May 1, 1992·The Annals of Thoracic Surgery·S R GundryL L Bailey
Jun 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·S R GundryL L Bailey
Jan 27, 1995·Transplantation·A CasavillaT Starzl
Jan 8, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·J MartinF Beyersdorf
Oct 8, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Arun K SinghalBruce I Goldman
Nov 14, 2006·Transplantation Proceedings·M Almenar-PertejoA Salvador
Aug 16, 2008·The New England Journal of Medicine·Mark M BoucekUNKNOWN Denver Children's Pediatric Heart Transplant Team
Jan 2, 2009·The New England Journal of Medicine·Cyril MoersRutger J Ploeg
Mar 31, 2009·Transplantation Proceedings·O DetryP Honoré
Apr 3, 2009·The New England Journal of Medicine·Christopher RayDavid Talbot
Jul 25, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D J ReichUNKNOWN ASTS Standards on Organ Transplantation Committee
Aug 22, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Satoru OsakiTakushi Kohmoto
Dec 17, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Olivier DetryRoberto Troisi
Apr 27, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Stephen RepseFranklin L Rosenfeldt
Apr 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A S KleinA O Ojo
Jul 16, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Marius BermanStephen Large
Sep 14, 2010·Transplantation Proceedings·H LedinhO Detry
Apr 21, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Beatriz Domínguez-GilUNKNOWN European Committee (Partial Agreement) on Organ Transplantation. Council of Europe (CD-P-TO)
Jan 10, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Hieu LedinhOlivier Detry
Mar 31, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C AignerW Klepetko
May 23, 2012·The Annals of Thoracic Surgery·David P MasonGösta B Pettersson
Jun 6, 2012·Transplantation Proceedings·O DetryM Meurisse

❮ Previous
Next ❯

Citations

Oct 22, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Simon Messer, Stephen Large
Mar 6, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Herman TolboomVolkmar Falk
May 24, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Simon MesserSteven Tsui
Apr 6, 2017·Current Opinion in Organ Transplantation·Kumud K DhitalPeter S Macdonald
Mar 18, 2017·Current Opinion in Organ Transplantation·Jacqueline M SmitsGuenther Laufer
Apr 18, 2018·Circulation. Heart Failure·Taufiek Konrad Rajab, Steve K Singh
Sep 19, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Maryjane FarrSean Pinney
Jan 4, 2020·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Kimia HonarmandIan M Ball
Jan 4, 2020·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Kimia HonarmandIan M Ball
Aug 24, 2017·Transplantation·Olivier DetryUNKNOWN Belgian Transplantation Society (BTS)
Apr 17, 2014·Nature Reviews. Cardiology·Sarah L LongnusHendrik T Tevaearai
May 21, 2019·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Matthias FuchsMatthias Siepe
Mar 21, 2019·Experimental Biology and Medicine·Meghan Pinezich, Gordana Vunjak-Novakovic
May 12, 2019·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Ian M BallRobert Sibbald
Aug 25, 2020·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Catherine Dushyanthy Sudarshan
Mar 1, 2018·Frontiers in Cardiovascular Medicine·Christopher W WhiteDarren H Freed
Apr 19, 2019·Circulation. Heart Failure·Petra NiederbergerSarah L Longnus
Mar 18, 2017·Current Opinion in Cardiology·Reema HasanDaniel Goldstein
Nov 7, 2020·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·S RoestO C Manintveld
Apr 5, 2020·The Journal of Thoracic and Cardiovascular Surgery·Taufiek Konrad RajabDavid N Campbell
Nov 20, 2020·Transplantation·Laura Anguela-CalvetEva Oliver-Juan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.