PMID: 9429731Jan 16, 1998Paper

What is the relationship between osteoarthritis and ageing?

Baillière's Clinical Rheumatology
T B Kirkwood

Abstract

The relationship between osteoarthritis and ageing raises important questions about what exactly defines 'normal' ageing and whether the pathogenesis of osteoarthritis shares common pathways with other age-associated dysfunctions, or whether osteoarthritis is a time-dependent disorder distinct from normal ageing with a separate causative mechanism at work. Theories of ageing now emphasize the stochastic nature of the ageing process, that is the role played by accumulation of essentially random cell and tissue damage, such as somatic mutations, oxidative damage and the formation of aberrant proteins. The role of genetic factors in determining longevity and predisposition to age-associated diseases is probably in programming the efficiency of somatic maintenance functions and in influencing the development of a durable soma. Gene-environment interactions, for example through lifestyle, can also be important. Many of the risk factors and mechanisms that are thought to contribute to osteoarthritis can be accommodated within this framework.

References

Mar 1, 1991·Mutation Research·T B Kirkwood
Jun 1, 1990·Aging : Clinical and Experimental Research·J Vijg
Jan 1, 1986·Journal of Chronic Diseases·J A Brody, E L Schneider
Oct 1, 1995·Mutation Research·B KadenbachJ Napiwotzki
Jul 1, 1993·Journal of the American Geriatrics Society·D Hamerman

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Citations

Jan 2, 2004·Aging Clinical and Experimental Research·Gaetano Crepaldi, Leonardo Punzi
Dec 17, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Andras HeijinkC Niek Van Dijk
May 9, 2018·American Journal of Physical Anthropology·Stephanie E CalceLisa Gould
Aug 12, 2005·Spine·Gali DarIsrael Hershkovitz

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