PMID: 11930106Apr 4, 2002Paper

What is the relationship between P-glycoprotein and adhesion molecule expression in melanoma cells?

Melanoma Research
Agnese MolinariGiuseppe Arancia

Abstract

A number of studies have reported that increased P-glycoprotein expression in drug-resistant tumour cells may be associated with decreased expression of a family of surface glycoproteins. However, despite its potential biological and clinical relevance, this phenomenon has not been extensively studied. In this study the phenotypic alterations that are associated with the acquisition of the multidrug-resistant phenotype in tumour cells, together with drug transporter overexpression, were investigated in human melanoma cells. The expression of cell adhesion molecules was analysed in a panel of multidrug-resistant melanoma cell lines (M14Dx) showing different degrees of resistance to doxorubicin and different levels of the expression of the drug transporter P-glycoprotein. In particular, expression of intercellular adhesion molecule-1 (ICAM-1), CD44, very late activation antigen (VLA)-5 and VLA-2 was determined by flow cytometry in the different resistant cell lines. A progressive downregulation of all the adhesion molecules examined was revealed in M14Dx cells, in parallel with an increasing level of expression of the drug transporter P-glycoprotein. The results obtained raise the question of the role of P-glycoprotein in the inv...Continue Reading

References

Oct 21, 1992·International Journal of Cancer. Journal International Du Cancer·M CianfrigliaJ Schröder
Jan 15, 1990·International Journal of Cancer. Journal International Du Cancer·M CianfrigliaF Malavasi
Sep 30, 1991·International Journal of Cancer. Journal International Du Cancer·M CianfrigliaM Caserta
Jan 1, 1985·Pharmacology & Therapeutics·J R Riordan, V Ling
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·N RichertI Pastan
Jan 1, 1995·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·G N van MuijenD J Ruiter
Dec 1, 1996·The British Journal of Dermatology·C A HarwoodM G Cook
May 8, 2000·International Journal of Cancer. Journal International Du Cancer·T HaradaM Wada

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Citations

Oct 19, 2007·The Journal of Investigative Dermatology·Marisa ColoneAgnese Molinari
Mar 27, 2004·Biochemical and Biophysical Research Communications·Nadezhda I KozlovaAlbert E Berman
Dec 4, 2002·Japanese Journal of Cancer Research : Gann·Ching-Ping TsengKelvin Chingchung Tseng

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