What is the restriction point?

Current Opinion in Cell Biology
A ZetterbergK G Wiman

Abstract

The restriction point (R) separates two functionally different parts of G1 in continuously cycling cells. G1-pm represents the postmitotic interval of G1 that lasts from mitosis to R. G1-ps represents the pre S phase interval of G1 that lasts from R to S. G1-pm is remarkably constant in length (its duration is about three hours) in the different cell types studied so far. G1-ps, however, varies considerably, indicating that entry into S is not directly followed after passage through R. Progression through G1-pm requires continuous stimulation by mitogenic signals (e.g. growth factors) and a high rate of protein synthesis. Interruption of the mitogenic signals or moderate inhibition of protein synthesis leads to a rapid exit from the cell cycle to G0 in normal (untransformed) cells. Upon restimulation with mitogenic signals, the cell returns to the same point in G1-pm from which it left the cell cycle. Thus the cell seems to have a memory for how far it has advanced through G1-pm, suggesting that a continuous structural alteration, for example chromatin decondensation, takes place in G1. The molecular background to transition from growth factor dependence in G1-pm to growth factor independence in G1-ps (a switch which represents...Continue Reading

References

Jan 1, 1991·Cold Spring Harbor Symposia on Quantitative Biology·A Zetterberg, O Larsson
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A Zetterberg, O Larsson
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·A B Pardee
Oct 1, 1971·Journal of Cellular Physiology·H M Temin
Jun 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G H Stein, V Dulić
Jun 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Y Sanchez, S J Elledge
May 1, 1995·Trends in Genetics : TIG·R Müller
Jul 1, 1995·Molecular and Cellular Biology·D Resnitzky, S I Reed
Jan 1, 1995·Advances in Cancer Research·G Selivanova, K G Wiman
Jan 1, 1995·Cell Proliferation·O Larsson, A Zetterberg
Jun 1, 1994·The Journal of Cell Biology·R D MoirR D Goldman
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·X Q QinP D Adams
Nov 4, 1993·Nature·M S Brown, J L Goldstein
Dec 1, 1993·Experimental Cell Research·C A AfshariJ C Barrett

❮ Previous
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Citations

Mar 1, 1997·The Journal of Pathology·D M Barnes
Sep 30, 1999·International Journal of Cancer. Journal International Du Cancer·M S BenassiP Picci
Jul 19, 2000·Mental Retardation and Developmental Disabilities Research Reviews·V S CavinessR S Nowakowski
Feb 25, 2011·Bulletin of Mathematical Biology·S Seirin LeeR E Baker
Apr 1, 1996·Critical Reviews in Oncology/hematology·O Larsson
Mar 20, 2013·Trends in Endocrinology and Metabolism : TEM·David A Foster
Apr 9, 2005·Experimental Cell Research·Hanna-Stina MartinssonAnders Zetterberg
Sep 21, 2002·Biochimica Et Biophysica Acta·Nghia T V Le, Des R Richardson
Dec 1, 1996·Current Opinion in Cell Biology·J BartekJ Lukas
Jan 13, 1998·Current Opinion in Cell Biology·M D Planas-Silva, R A Weinberg
Jan 16, 2002·Current Opinion in Genetics & Development·Alan Ho, Steven F Dowdy
Jun 8, 2000·Bioorganic & Medicinal Chemistry Letters·K K MurthiK Pal
Mar 10, 2001·Trends in Cardiovascular Medicine·U Laufs, J K Liao
Feb 19, 2000·Current Opinion in Chemical Biology·C M Crews, R Mohan
Mar 5, 1999·Breast Cancer Research and Treatment·D M Barnes, C E Gillett
Mar 28, 2008·Nature Cell Biology·Guang YaoLingchong You
Jan 5, 2000·Cell Proliferation·B D Aguda, Y Tang
Jun 10, 1998·Immunology and Cell Biology·J GómezA Rebollo
Dec 14, 1999·The European Journal of Neuroscience·S R SinclairS B Dunnett
Oct 10, 2002·Kidney International·Baolian Liu, Patricia A Preisig
Dec 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Claude Gérard, Albert Goldbeter
Jul 21, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kasturi MitraJennifer Lippincott-Schwartz
Dec 5, 2009·Proceedings of the National Academy of Sciences of the United States of America·Louis-Jan PilazColette Dehay
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·M Tyers
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·Z M WangD M Livingston
Nov 9, 2000·Proceedings of the National Academy of Sciences of the United States of America·J R YehC M Crews
Oct 1, 2008·Journal of Biological Dynamics·Peter Olofsson
May 15, 2004·DNA and Cell Biology·Shohreh AminiBassel E Sawaya
Mar 13, 2003·Molecular Biology of the Cell·Christoph Schorl, John M Sedivy
Jan 24, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hong Wa YungGraham J Burton
Mar 16, 2012·Interface Focus·Claude Gérard, Albert Goldbeter
Mar 15, 2013·Open Biology·Anael VerdugoBela Novak
Mar 11, 1999·Genes & Development·M SchreiberE F Wagner
Apr 5, 2001·Molecular and Cellular Biology·S V EkholmA Zetterberg
Dec 2, 2004·Molecular and Cellular Biology·Brandt L SchneiderBruce Futcher
Sep 17, 2005·Molecular and Cellular Biology·Montserrat Blázquez-DomingoMarieke von Lindern

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