What is the role of particle morphology in pharmaceutical powder aerosols?

Expert Opinion on Drug Delivery
Hak-Kim Chan

Abstract

The aerosol performance of a powder for inhalation drug delivery is controlled by a number of physicochemical properties of the formulation, including particle size, density and morphology. The role of particle morphology in powder inhalers will be reviewed. Original research publications in the literature about the contribution of particle morphology to the aerosol performance of pharmaceutical powders have been selected, including both the lactose carriers and the drugs. Existing data showed that morphology of both the lactose carrier and drug particle can affect the aerosol performance of powders significantly, a factor which should be taken into consideration during the development of dry powder inhalation products.

References

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Citations

Nov 13, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·S StegemannA Hincal
Feb 18, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Yoen-Ju Son, Jason T McConville
Feb 23, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Michiko KumonHak-Kim Chan
Aug 26, 2015·International Journal of Pharmaceutics·Cordula WeissHelen Cathcart
Aug 14, 2012·The Journal of Pharmacy and Pharmacology·Yoen-Ju Son, Jason T McConville
Apr 20, 2016·Pharmaceutical Research·Bernice Mei Jin TanPaul Wan Sia Heng
Feb 14, 2015·The Journal of Pharmacy and Pharmacology·Martyn David Ticehurst, Ivan Marziano
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May 27, 2016·Pharmaceutical Research·Hideyuki SatoSatomi Onoue
Jul 28, 2016·Scientific Reports·Minggan LiDae Kun Hwang
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Apr 5, 2021·International Journal of Pharmaceutics·Shadi YaqoubiHamed Hamishehkar
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Aug 29, 2021·Pharmaceutics·Li DingHugh D C Smyth
Sep 12, 2021·International Journal of Pharmaceutics·Gajendra SinghAgisilaos Kourmatzis

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