What is the role of the D3 receptor in addiction? A mini review of PET studies with [(11)C]-(+)-PHNO

Progress in Neuro-psychopharmacology & Biological Psychiatry
Doris E PayerIsabelle Boileau

Abstract

The chronic use of drugs, including psychostimulants such as cocaine and amphetamine, has been associated with low D2/3 dopamine receptor availability, which in turn has been linked to poor clinical outcome. In contrast, recent studies focused on the D3 receptor (a member of the D2-like receptor family) suggest that chronic exposure to stimulant drugs can up-regulate this receptor subtype, which, in preclinical models, is linked to dopamine system sensitization - a process hypothesized to contribute to relapse in addiction. In this mini review we present recent human data suggesting that the D3 receptor may contribute to core features of addiction, and discuss the usefulness of the PET imaging probe [(11)C]-(+)-PHNO in investigating this question.

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Related Concepts

Central Nervous System Stimulant [EPC]
Amphetamine
Adrenal Cortex Diseases
Central Nervous System Stimulants
Globus Pallidus
Dopamine D3 receptor
Neostriatum
Positron-Emission Tomography
Heroin
Pre-Clinical Model

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