What Is the Success of Repeat Surgical Treatment of a Local Recurrence After Initial Wide Resection of Soft Tissue Sarcomas?

Clinical Orthopaedics and Related Research
Hideshi SugiuraYoshihiro Nishida

Abstract

Treatment for patients with locally recurrent soft tissue sarcomas after wide resection is challenging, and few studies have examined the results of treating these patients. In treatment of recurrent tumors, it has been reported that positive margins are correlated to local rerecurrence, but the relationship between surgical margin and survival remains controversial and risk factors for local recurrences after wide resection of soft tissue sarcomas are not well established. This study examined clinical outcomes and factors associated with survival and local rerecurrence in patients with local recurrence after initial surgical treatment who underwent another resection with a goal of negative margins. The purpose of this study was to determine (1) oncologic outcomes (survival rates and local rerecurrence-free rates) of surgical treatment for patients with local recurrence after wide resection; (2) whether factors associated with survival and local rerecurrence-free rates can be determined; and (3) the proportion of patients treated by amputation at final followup. Between 1992 and 2013, we treated 530 patients with soft tissue sarcoma without metastasis. Of those, 26 (5%) were lost before 3 years of followup but were not known to...Continue Reading

References

Jun 1, 1991·International Journal of Radiation Oncology, Biology, Physics·D NoriK Shupak
Jul 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M RobinsonG Westbury
Jul 1, 1982·Annals of Surgery·A E GiulianoD L Morton
May 1, 1996·Annals of Surgical Oncology·C P KarakousisD L Driscoll
Feb 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J J LewisM F Brennan
Mar 1, 2000·Journal of Surgical Oncology·J F GibbsW G Kraybill
May 16, 2001·Annals of Surgical Oncology·R C RamanathanJ M Thomas
Jul 18, 2001·Annals of Surgical Oncology·A StojadinovicM F Brennan
Jul 23, 2003·Current Opinion in Oncology·Stephen R Grobmyer, Murray F Brennan
Aug 7, 2003·American Journal of Clinical Oncology·Esra KaytanEmin Darendeliler
Apr 14, 2005·Annals of Surgical Oncology·Fritz C EilberSamuel Singer
Jan 9, 2007·International Journal of Radiation Oncology, Biology, Physics·Mylin A TorresGunar K Zagars
Jan 30, 2007·Annals of Surgical Oncology·Alessandro GronchiPaolo G Casali
Feb 14, 2007·Annals of Surgical Oncology·Murray F Brennan
Aug 12, 2010·Clinical Orthopaedics and Related Research·Sarantis AbatzoglouDavid Roberge
Oct 2, 2013·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hideshi SugiuraKenji Yamada
Aug 6, 2016·Annals of Surgical Oncology·Sylvie BonvalotCécile Le Péchoux

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Citations

Feb 7, 2020·Current Treatment Options in Oncology·Elyse J BrinkmannMatthew T Houdek
Jan 1, 2022·The Bone & Joint Journal·Laura J HartleyScott Evans

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