What lurks beneath: IL-11, via Stat3, promotes inflammation-associated gastric tumorigenesis.

The Journal of Clinical Investigation
Juanita L Merchant

Abstract

Chronic inflammation in the stomach induces cellular transformation and gastric cancer primarily in the distal stomach or antrum. In this issue of the JCI, a study in mice by Ernst et al. provides new insight into the role of IL-11 and its glycoprotein 130 (gp130) receptor in inflammation-associated gastric epithelial cell oncogenic transformation, which they show is mediated by and dependent on increased activation of Stat3 and, to a lesser extent, Stat1 (see the related article beginning on page 1727). Prior studies from this group have shown that Stat3 hyperactivity stimulates the TGF-beta inhibitor Smad7. Collectively, the studies suggest that an important pathway of oncogenic transformation in the stomach is through suppression of growth inhibitory signals, such as members of the TGF-beta family, that originate from the stroma.

References

Jul 12, 1975·Lancet·P CorreaM Archer
Mar 5, 2002·Gastroenterology·Debra G SilbergKlaus H Kaestner
Mar 29, 2002·Cancer·Hala M T El-ZimaityTsutomu Katsuyama
May 8, 2002·The Journal of Clinical Investigation·Jacqueline Bromberg
Apr 8, 2003·World Journal of Gastroenterology : WJG·Chun-Yang WenIchiro Sekine
Nov 3, 2004·Cancer Research·Hiroyuki MutohKentaro Sugano
Jul 20, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aime T FrancoRichard M Peek
Aug 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Guillermo I Perez-PerezAsalia Z Olivares
Sep 5, 2006·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Tetsuya TsukamotoMasae Tatematsu
Aug 25, 2007·Journal of Gastroenterology and Hepatology·Mitsushige SugimotoAkira Hishida
Apr 24, 2008·The Journal of Clinical Investigation·Matthias ErnstBrendan J Jenkins

❮ Previous
Next ❯

Citations

May 19, 2012·TheScientificWorldJournal·Petra Hudler
Sep 5, 2008·Journal of Virology·Tatsuo KandaRatna B Ray
Sep 2, 2011·The Journal of Clinical Investigation·Jennifer Nancy HahnFrank Robert Jirik
Mar 7, 2012·International Journal of Biological Sciences·Zhenwei ZhangBinghua Jiao
Mar 31, 2009·Journal of Cancer Research and Clinical Oncology·Wei-Qing XuGuo-Hui Fu
Mar 29, 2014·Frontiers in Immunology·Kevin H Toomer, Zhibin Chen
May 18, 2016·The Journal of Infectious Diseases·Galina ShepelkovaAlexander Apt
Jan 26, 2017·Journal of Cellular Physiology·Vahid BagheriMohammad Reza Abbaszadegan

❮ Previous
Next ❯

Methods Mentioned

BETA
antisense oligonucleotides

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.