What makes biochemical networks tick?

European Journal of Biochemistry
Boris N GoldsteinMarta Cascante

Abstract

In view of the increasing number of reported concentration oscillations in living cells, methods are needed that can identify the causes of these oscillations. These causes always derive from the influences that concentrations have on reaction rates. The influences reach over many molecular reaction steps and are defined by the detailed molecular topology of the network. So-called 'autoinfluence paths', which quantify the influence of one molecular species upon itself through a particular path through the network, can have positive or negative values. The former bring a tendency towards instability. In this molecular context a new graphical approach is presented that enables the classification of network topologies into oscillophoretic and nonoscillophoretic, i.e. into ones that can and ones that cannot induce concentration oscillations. The network topologies are formulated in terms of a set of uni-molecular and bi-molecular reactions, organized into branched cycles of directed reactions, and presented as graphs. Subgraphs of the network topologies are then classified as negative ones (which can) and positive ones (which cannot) give rise to oscillations. A subgraph is oscillophoretic (negative) when it contains more positive ...Continue Reading

References

Jan 1, 1977·Archives of Oral Biology·M W Hill
Jan 1, 1977·Progress in Biophysics and Molecular Biology·R HeinrichT A Rapoport
Dec 1, 1987·Cell Biophysics·H V WesterhoffR J Wanders
Nov 21, 1988·Journal of Theoretical Biology·C Reder
Feb 7, 1985·Journal of Theoretical Biology·B N Goldstein, E L Shevelev
Feb 28, 1966·Biochimica Et Biophysica Acta·M V Volkenstein, B N Goldstein
Jul 21, 1983·Journal of Theoretical Biology·B N Goldstein
May 30, 1994·FEBS Letters·V A SelivanovB N Goldstein
Oct 28, 1998·Nature·M J BerridgeP Lipp
Jul 20, 2001·Metabolic Engineering·H V Westerhoff
Mar 5, 2002·European Journal of Biochemistry·Stefan SchusterThomas Höfer
May 30, 2003·Biochemical Society Transactions·A G McDonald
Jun 26, 2003·European Journal of Biochemistry·Lars F OlsenUrsula Kummer
Jun 28, 2003·Biophysical Journal·Pål O Westermark, Anders Lansner
Oct 3, 2003·The Journal of Biological Chemistry·Michael J MacDonaldMindy A Kendrick
Jan 20, 2004·Nature Genetics·Galit LahavUri Alon

❮ Previous
Next ❯

Citations

Apr 21, 2005·Physical Chemistry Chemical Physics : PCCP·Sune DanøPreben G Sørensen
Oct 20, 2009·Biophysical Chemistry·B N GoldsteinD T Zakrjevskaya
Aug 7, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Thomas Wilhelm

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolic Reprogramming (Keystone)

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Cancer Metabolic Reprogramming

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.