Abstract
There are still ongoing controversies as to which histological parameters allow the diagnosis of gastroesophageal reflux disease (GERD). The aim of the present analysis was to relate histological changes of the esophageal squamous epithelium to different severities of GERD. Data were obtained from patients participating in the ProGERD study, who had either erosive reflux disease (ERD, n = 3,245) or non-erosive reflux disease (NERD, n = 2,970). 1,475 patients fulfilled our requirement of having complete biopsy data from two sites (2 cm above the z-line and at the z-line). Changes in the squamous epithelium were assessed by measuring the thickness of the basal cell layer and elongation of the papillae as a percentage of the whole epithelial thickness and counting interepithelial inflammatory cells. The most useful parameters for histological assessment of GERD (given as means, 2 cm above the z-line and at the z-line, respectively) were elongation of the papillae: NERD 40.7 and 48.9%; ERD 46.1 and 54.9% and basal cell hyperplasia: NERD 12.7 and 17.9%; ERD 15.7 and 23.0%. The occurrence of intraepithelial lymphocytic infiltrates, however, is dependent on the severity of GERD, and they are more common than neutrophilic and eosinophi...Continue Reading
Citations
Jul 16, 2008·Current Gastroenterology Reports·Guido N J Tytgat
Sep 22, 2012·BMC Gastroenterology·Klaus MönkemüllerPeter Malfertheiner
Nov 6, 2010·Digestive Diseases and Sciences·Helmut NeumannPeter Malfertheiner
Mar 3, 2011·Digestive Diseases and Sciences·Lisa YerianMagnus Ruth
Nov 5, 2011·Biological Chemistry·Anne-Kathrin RaabThomas Wex
Jan 6, 2006·Alimentary Pharmacology & Therapeutics·M ViethM Stolte
Apr 16, 2016·BMC Gastroenterology·Ekkehard BayerdörfferStefan Eklund
Oct 6, 2009·Human Pathology·Roberto FioccaMagnus Ruth
May 26, 2009·Peptides·Thomas WexPeter Malfertheiner
Dec 13, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·John Dent
Apr 24, 2012·Human Pathology·Thomas WexPeter Malfertheiner
Oct 15, 2013·Annals of the New York Academy of Sciences·Andrew M BellizziXiaoxin Chen
Nov 15, 2011·Digestion·Ulrike von ArnimPeter Malfertheiner
Nov 12, 2009·The American Journal of Gastroenterology·Roberto FioccaUNKNOWN LOTUS trial collaborators
Sep 7, 2018·Yonsei Medical Journal·In Ji SongSang Kil Lee
Sep 27, 2005·The American Journal of Gastroenterology·Patrizia ZentilinRoberto Fiocca
Jun 19, 2008·Alimentary Pharmacology & Therapeutics·K MonkemullerP Malfertheiner
Dec 17, 2008·Histopathology·S MuellerM Stolte
Feb 13, 2009·European Journal of Gastroenterology & Hepatology·Thomas WexPeter Malfertheiner
Feb 20, 2007·Alimentary Pharmacology & Therapeutics·L MastracciR Fiocca
Sep 1, 2005·Journal of Pediatric Gastroenterology and Nutrition·Eric Hassall
Nov 23, 2011·Nature Reviews. Gastroenterology & Hepatology·Arne Kandulski, Peter Malfertheiner
Apr 28, 2009·Advances in Anatomic Pathology·Daniela S Allende, Lisa M Yerian
Jan 27, 2012·Histopathology·Thomas WexPeter Malfertheiner
Dec 29, 2012·Scandinavian Journal of Gastroenterology·Eleonora BjörkmanLars Fändriks
Jul 31, 2013·Alimentary Pharmacology & Therapeutics·A KandulskiP Malfertheiner
Jul 16, 2010·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·R CuiX Yan
Jun 29, 2021·Human Pathology·Mudar Zand IraniMarjorie M Walker
Jul 29, 2008·Best Practice & Research. Clinical Gastroenterology·Michael Vieth
Oct 14, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M RibolsiM Cicala