What percentage of patients with newly diagnosed carcinoma of the prostate are candidates for surveillance? An analysis of the CaPSURE database

The Journal of Urology
Daniel A BarocasCaPSURE Investigators

Abstract

Active surveillance is an option for men with clinically localized prostate cancer and may be suitable for those with very low risk disease. We determined the percentage of men in a large prostate cancer registry who met criteria predictive of latent prostate cancer. We also assessed the percentage of men meeting these criteria who chose surveillance. We conducted an observational study of 1,886 men diagnosed with clinically localized prostate cancer between 1999 and 2004 from the CaPSURE database. Outcomes were percent of men meeting Epstein surveillance criteria (prostate specific antigen less than 10 ng/ml, clinical T1 or T2a, prostate specific antigen density less than 0.15, fewer than 1 of 3 biopsy cores positive, and absence of Gleason pattern 4 and 5 on biopsy) and percent selecting surveillance stratified by risk group. Of 1,886 men with all 5 criteria documented 16.4% (310 of 1,886) met all 5 surveillance criteria and 9.0% (28 of 310) of men in this very low risk category actually chose surveillance compared with 4.3% (68 of 1,576) of patients in other risk groups (p <0.01). On multivariable analysis of the entire cohort older age was the only demographic predictor of surveillance. Being in the very low risk group was ...Continue Reading

References

Feb 2, 1994·JAMA : the Journal of the American Medical Association·J I EpsteinC B Brendler
Jun 1, 1997·The Journal of Urology·H B CarterJ I Epstein
Nov 26, 1999·Scandinavian Journal of Urology and Nephrology. Supplementum·T Nevéus
Dec 26, 2001·Journal of the National Cancer Institute·L C HarlanR A Stephenson
Feb 8, 2002·The Journal of Urology·H Ballentine CarterJonathan I Epstein
Jun 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew R CooperbergPeter R Carroll
May 5, 2005·JAMA : the Journal of the American Medical Association·Peter C AlbertsenJudith Fine
May 13, 2005·The New England Journal of Medicine·Anna Bill-AxelsonUNKNOWN Scandinavian Prostate Cancer Group Study No. 4
Oct 1, 2005·Urology·Kirsten L GreeneUNKNOWN Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) Investigators
Nov 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laurence Klotz
Mar 2, 2006·Journal of the National Cancer Institute·Christopher WarlickH Ballentine Carter
Aug 17, 2006·Journal of the National Cancer Institute·David C MillerJohn T Wei
Jan 24, 2007·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun

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Citations

Dec 2, 2010·JAMA : the Journal of the American Medical Association·Julia H HayesPamela M McMahon
Apr 17, 2013·Abdominal Imaging·Fergus V CoakleyAaron B Caughey
Jul 3, 2008·World Journal of Urology·Joseph A Smith
Feb 25, 2011·World Journal of Urology·Sima P PortenPeter R Carroll
Dec 7, 2011·Prostate Cancer and Prostatic Diseases·M A GorinM S Soloway
May 19, 2010·Journal of Endourology·Uri LindnerJohn Trachtenberg
Jun 11, 2010·Japanese Journal of Clinical Oncology·Mikio SugimotoYoshiyuki Kakehi
Dec 1, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew R CooperbergPeter R Carroll
Oct 17, 2012·PloS One·Men Long LiongChoong Chin Liew
May 1, 2012·Lancet·Neil E Fleshner, UNKNOWN REDEEM trial investigators
Apr 12, 2011·Urology·Peter R Carroll, Jared M Whitson
Aug 3, 2010·International Journal of Radiation Oncology, Biology, Physics·Juanita CrookClement Ma
Mar 23, 2010·The Journal of Urology·Kenneth S TsengH Ballentine Carter
Sep 18, 2009·The Journal of Urology·William J Catalona
Aug 18, 2009·The Journal of Urology·U LindnerJ Trachtenberg
Mar 17, 2009·European Urology·Patrick J BastianFritz Schröder
Apr 22, 2011·BJU International·B Joyce Davison, S Larry Goldenberg
Feb 16, 2010·The Urologic Clinics of North America·Andrew J StephensonEric A Klein
May 12, 2015·CA: a Cancer Journal for Clinicians·Christopher P FilsonMark S Litwin
Apr 8, 2015·The Journal of Urology·Scott E EggenerWilliam T Lowrance
Feb 21, 2016·Journal of Racial and Ethnic Health Disparities·Jinping XuKendra L Schwartz
Dec 20, 2011·Patient Education and Counseling·Barbara Joyce Davison, Erin Breckon

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