PMID: 2106843Mar 1, 1990Paper

What rate of infusion of intravenous nutrition solution is required to stimulate uptake of amino acids by peripheral tissues in depleted patients?

Annals of Surgery
P B LoderT S Reeve

Abstract

We examined the effect of varying the quantities (0, 0.1, 0.2, 0.3, and 0.4 gN.kg-1.[day]-1) of nitrogen input on N balance, 3-methylhistidine (3MH) excretion, plasma amino acid concentration and the net flux of amino acids across the leg in depleted patients requiring parenteral nutrition. The calorie-to-nitrogen ratio was 140 to 1 (kcal:1 gN) and consequently the patients received varying amounts of calories (8, 14, 28, 42, and 56 kcal.kg-1.[day]-10. There was negative nitrogen balance and net loss of amino acids from the limb during fasting. An infusion of 0.2 gN.kg-1.[day]-1 of IVN reversed the net catabolic process and resulted in equilibrium of peripheral total amino acid flux and of tyrosine flux without a decrease in 3MH excretion. Net uptake of total amino acids and tyrosine in peripheral tissues was achieved with 0.4 gN.kg-1.[day]-1 and 56 kcal.kg-1.[day]-1. This was associated with a fivefold increase in 3MH excretion (p less than 0.01), indicating that net anabolism occurred with increased protein turnover. Fifty per cent of the amino acids taken up by peripheral tissues during infusions of 0.4 gN.kg-1.[day]-1 was due to the uptake of glutamate (Glu) and 20% was due to the uptake of branched chain amino acids (BCAA)...Continue Reading

References

Jul 1, 1979·JPEN. Journal of Parenteral and Enteral Nutrition·G L HillD B Morgan
Sep 1, 1987·The Journal of Clinical Investigation·K LundholmA C Möller-Loswick
Sep 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·C R KapadiaD W Wilmore
Jan 1, 1984·The British Journal of Surgery·G L Hill, J Church
Nov 1, 1983·JPEN. Journal of Parenteral and Enteral Nutrition·S D AngT P Stein
Jan 1, 1980·Critical Care Medicine·D H Elwyn
May 1, 1982·Metabolism: Clinical and Experimental·N N AbumradW W Lacy
Mar 1, 1982·JPEN. Journal of Parenteral and Enteral Nutrition·A M KlidjianS J Karran

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Citations

Jul 31, 1998·Nutrition·D W Wilmore, J K Shabert
Sep 5, 1991·The New England Journal of Medicine·D W Wilmore
Nov 1, 1994·Clinical Endocrinology·G Van den BergheJ D Veldhuis
Jan 1, 1994·Annual Review of Medicine·T R ZieglerD W Wilmore
Aug 1, 1993·Metabolism: Clinical and Experimental·A J Kee, R C Smith
Aug 1, 1994·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·R G Barton
Jan 1, 1993·JPEN. Journal of Parenteral and Enteral Nutrition·F BozzettiL Gennari
Feb 1, 2007·American Journal of Physiology. Endocrinology and Metabolism·Dominic S C RajArny Ferrando
Jul 17, 1999·The American Journal of Physiology·A J KeeR C Smith
Oct 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·A SevetteR C Smith

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