What should be the core outcomes in chronic pain clinical trials?

Arthritis Research & Therapy
Dennis C Turk, Robert H Dworkin

Abstract

A consensus conference with representatives from academia, governmental agencies, and the pharmaceutical industry met and concluded that clinical trials designed to assess the efficacy and effectiveness of treatments for chronic pain should consider outcomes in six core domains: pain, physical functioning, emotional functioning, patient global ratings of satisfaction, negative health states and adverse events, and patient disposition. In addition, it was acknowledged that there are many secondary domains that might be of importance and should be included in trials depending on the nature of the treatment and population to whom the treatment is targeted.

References

Apr 17, 2001·Annals of Internal Medicine·D MoherUNKNOWN CONSORT GROUP (Consolidated Standards of Reporting Trials)

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Citations

Feb 6, 2007·The Clinical Journal of Pain·Steven P CohenMilan P Stojanovic
Mar 3, 2007·BMC Musculoskeletal Disorders·Sedigheh Sadat TavafianAli Montazeri
Apr 2, 2009·Neuropsychiatric Disease and Treatment·Kim Lawson
Jan 1, 2012·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Syeda SerajMohammed Rahmatullah
Sep 7, 2012·World Journal of Cardiology·Dioma U UdeojiErnst R Schwarz
Jun 11, 2009·American Journal of Pharmaceutical Education·Dana J JameroLinda Mihm
Jul 14, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Kayode A WilliamsSteven P Cohen
Aug 27, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Ericka N MerriwetherKathleen A Sluka
Jun 19, 2008·Journal of Manipulative and Physiological Therapeutics·Raheleh KhorsanChristine Goertz Choate
Sep 23, 2014·Image and Vision Computing·Karan SikkaMarian Stewart Bartlett
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Kinjal C PatelPaul Michael J Peloso
Jul 12, 2011·Therapeutic Drug Monitoring·Sondra VanderVaartGideon Koren
Nov 20, 2012·Pain Practice : the Official Journal of World Institute of Pain·Deepmala DeepmalaWei Jiang
Oct 28, 2019·Advances in Rheumatology·Gabriel Horta-Baas, Maria Del Socorro Romero-Figueroa
Nov 26, 2011·Journal of Oral Rehabilitation·C M C Van Der LugtC M Visscher
Sep 25, 2016·Journal of Neuroengineering and Rehabilitation·Anisoara Paraschiv-IonescuKamiar Aminian
Oct 28, 2020·Physiological Measurement·Somayeh AfrasiabiMohammad-Ali Masnadi-Shirazi
Nov 8, 2016·Scandinavian Journal of Pain·Sarah A KelleherAmy P Abernethy
Jan 5, 2011·Clinical Therapeutics·W Jacqueline KwongShane Kavanagh

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Software Mentioned

IMMPACT
WOMAC

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