What Should Be the Primary Target of "Treat to Target" in Psoriatic Arthritis?

The Journal of Rheumatology
Laura C CoatesPhilip S Helliwell

Abstract

Recommendations regarding "treat to target" in psoriatic arthritis (PsA) have stated that the target should be remission or inactive disease. Potential definitions include very low disease activity (VLDA), PsA Disease Activity Score (PASDAS) near remission, Disease Activity Index for PsA (DAPSA) or clinical DAPSA (cDAPSA) remission. Our aim was to investigate the proportion of patients who fulfill these definitions and how much residual active disease remained. This analysis used 2 datasets: first, trial data from the Tight Control of PsA (TICOPA) study, which included 206 patients with recent-onset (< 2 yrs) PsA receiving standard and biological disease-modifying antirheumatic drugs (DMARD); and second, an observational clinical dataset from Italy of patients receiving biological DMARD. Proportions achieving each of the 4 potential targets were calculated in each dataset and comparisons between treatment groups were performed in the TICOPA dataset. Levels of residual disease were established for key clinical domains of PsA. All measures could differentiate the TICOPA trial treatment groups (p < 0.03). Lower proportions of patients fulfilled the VLDA criteria compared to DAPSA or cDAPSA remission. PASDAS results were different ...Continue Reading

References

Dec 1, 1995·British Journal of Rheumatology·R M FrancisD J Torgerson
Aug 14, 2015·Annals of the Rheumatic Diseases·Monika M SchoelsJosef S Smolen
Dec 17, 2015·The Journal of Rheumatology·Laura C Coates, Philip S Helliwell
Dec 17, 2015·The Journal of Rheumatology·Fabio Massimo PerrottaEnnio Lubrano

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Citations

Aug 21, 2019·Rheumatology and Therapy·Ennio LubranoPhilip Helliwell
Nov 5, 2019·The Journal of Rheumatology·Ennio LubranoFabio Massimo Perrotta
Nov 5, 2019·The Journal of Rheumatology·Ennio LubranoFabio Massimo Perrotta
Jan 17, 2021·The Journal of Rheumatology·Ennio LubranoFabio Massimo Perrotta

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