What to do when a smoker's CT scan is "normal"?: Implications for lung cancer screening.

Chest
Joanna H ZurawskaDon D Sin

Abstract

Lung cancer is the leading cause of cancer-related mortality in the United States and around the world. There are > 90 million current and ex-smokers in the United States who are at increased risk of lung cancer. The published data from the National Lung Screening Trial (NLST) suggest that yearly screening with low-dose thoracic CT scan in heavy smokers can reduce lung cancer mortality by 20% and all-cause mortality by 7%. However, to implement this program nationwide using the NLST inclusion and exclusion criteria would be extremely expensive, with CT scan costs alone > $2 billion per annum. In this article, we offer a possible low-cost strategy to risk-stratify smokers on the basis of spirometry measurements and emphysema scoring by radiologists on CT scans.

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Citations

Feb 6, 2013·Chest·Tiffany A WinstoneDon D Sin
Apr 25, 2014·AJR. American Journal of Roentgenology·Mizuho NishioYoshiharu Ohno
Sep 1, 2015·Archivos de bronconeumología·Sergio ScriminiJaume Sauleda
Apr 9, 2016·AJR. American Journal of Roentgenology·Mizuho NishioKazuro Sugimura
May 1, 2015·BMC Pulmonary Medicine·Nicolas MolinariArnaud Bourdin
Jul 7, 2016·Journal of Radiation Research·Satoru OchiaiHajime Sakuma
Oct 11, 2014·World Journal of Clinical Oncology·Yuichi TakiguchiKoichiro Tatsumi
Dec 7, 2017·Current Opinion in Pulmonary Medicine·Abhishek BiswasErik E Folch

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