What Tumor Dynamics Modeling Can Teach us About Exploiting the Stem-Cell View for Better Cancer Treatment

Cancer Informatics
Roger S Day

Abstract

The cancer stem cell hypothesis is that in human solid cancers, only a small proportion of the cells, the cancer stem cells (CSCs), are self-renewing; the vast majority of the cancer cells are unable to sustain tumor growth indefinitely on their own. In recent years, discoveries have led to the concentration, if not isolation, of putative CSCs. The evidence has mounted that CSCs do exist and are important. This knowledge may promote better understanding of treatment resistance, create opportunities to test agents against CSCs, and open up promise for a fresh approach to cancer treatment. The first clinical trials of new anti-CSC agents are completed, and many others follow. Excitement is mounting that this knowledge will lead to major improvements, even breakthroughs, in treating cancer. However, exploitation of this phenomenon may be more successful if informed by insights into the population dynamics of tumor development. We revive some ideas in tumor dynamics modeling to extract some guidance in designing anti-CSC treatment regimens and the clinical trials that test them.

References

Apr 1, 1987·Appetite·P G OsborneR S Weisinger
May 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Annika JögiSven Påhlman
Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Muhammad Al-HajjMichael F Clarke
Apr 28, 2004·Current Opinion in Genetics & Development·Muhammad Al-HajjMichael F Clarke
Sep 8, 2004·Lancet·Bernard FisherUNKNOWN National Surgical Adjuvant Breast and Bowel Project randomised clinical trials
Sep 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·C Hirschmann-JaxM K Brenner
Apr 20, 2006·Artificial Intelligence in Medicine·Roger S Day
Feb 7, 2007·Cancer Research·Chenwei LiDiane M Simeone
Nov 22, 2007·Neoplasia : an International Journal for Oncology Research·Per Ø SakariassenMartha Chekenya
Nov 29, 2007·Annals of Surgical Oncology·Xiong-Zhi Wu
Oct 9, 2008·Journal of the National Cancer Institute·David F Ransohoff
Nov 26, 2008·Oncogene·G Moreno-BuenoA Cano
Dec 10, 2008·Blood·John E Dick
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Apr 8, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rachel Rabinovitch, Brian Kavanagh
Jul 8, 2009·Methods in Molecular Biology·Vera S DonnenbergAlbert D Donnenberg
Jan 7, 2010·The Journal of Clinical Investigation·Christophe GinestierMax S Wicha
Apr 14, 2010·Cancer Cell·Ruihuan ChenHeidi S Phillips
Apr 17, 2010·Bulletin of Mathematical Biology·Allen A Katouli, Natalia L Komarova
Aug 4, 2010·Journal of Theoretical Biology·Matthew D JohnstonWalter F Bodmer
Oct 5, 2010·Breast Cancer Research : BCR·Christophe GinestierDaniel Birnbaum
Oct 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Xiaolong WeiPatricia K Donahoe
Mar 10, 2011·Nature Medicine·Hans Clevers
Apr 9, 2011·Progress in Biophysics and Molecular Biology·Heiko Enderling, Philip Hahnfeldt
Apr 12, 2011·International Journal of Cancer. Journal International Du Cancer·Ilona KryczekWeiping Zou
Jan 3, 2012·Journal of Theoretical Biology·Vladimir VainsteinZvia Agur
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Katia MeirellesXiaolong Wei
Feb 22, 2012·Current Oncology Reports·Lise WillemsDidier Bouscary
Mar 13, 2012·International Journal of Molecular Sciences·Salvador J Diaz-Cano
Mar 24, 2012·Cancer Cell·Jeffrey A MageeSean J Morrison
Jun 14, 2012·Clinical & Developmental Immunology·Appalaraju Jaggupilli, Eyad Elkord
Jul 12, 2012·Nature Biotechnology·Sean C Bendall, Garry P Nolan
Oct 9, 2012·International Journal of Oncology·Christian LehmannManfred Kubbies
Jan 17, 2013·Journal of Clinical Pathology·Jabed IqbalPuay Hoon Tan

❮ Previous
Next ❯

Citations

Jan 17, 2016·Life Sciences·Vahid HaghpanahBagher Larijani

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft
xenografts

Software Mentioned

OncoTCap
StemCellActive
StandardChemo

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The International Journal of Developmental Biology
Yue ZhaoChristiane J Bruns
Pediatric Research
Wei GuoHong Wu
Methods in Molecular Biology
Virginia TirinoMario De Rosa
© 2021 Meta ULC. All rights reserved