What Type of Patients Did PARAGON-HF Select? Insights from a Real-World Prospective Cohort of Patients with Heart Failure and Preserved Ejection Fraction

Journal of Clinical Medicine
René RettlDiana Bonderman

Abstract

The PARAGON-HF clinical trial suggested that sacubitril/valsartan may become a treatment option for particular subgroups of patients with heart failure and preserved ejection fraction (HFpEF). However, the proportion of real-world HFpEF patients who are theoretically superimposable with the PARAGON-HF population is yet unknown. The present study was performed to define the proportion of real-world PARAGON-HF-like patients and to describe their clinical characteristics and long-term prognosis in comparison with those who would not meet PARAGON-HF criteria. We systematically applied PARAGON-HF inclusion and exclusion criteria to a total of 427 HFpEF patients who have been participating in a prospective national registry between December 2010 and December 2019. In total, only 170 (39.8%) registry patients were theoretically eligible for PARAGON-HF. Patients not meeting inclusion criteria (41.0%) were less impaired with respect to exercise capacity (median 6-min walk distance: 385 m (IQR: 300-450) versus 323 m (IQR: 240-383); p < 0.001) had lower pulmonary pressures (mean pulmonary artery pressure (mPAP): 31.2 mmHg, standard deviation (SD): ±10.2 versus 32.8 mmHg, SD: ±9.7; p < 0.001) and better outcomes (log-rank: p < 0.001) as co...Continue Reading

References

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Citations

Dec 21, 2020·European Journal of Heart Failure·Diana Bonderman
Mar 26, 2021·Oxidative Medicine and Cellular Longevity·Kacper Maksymilian MilMateusz Maciejczyk
May 1, 2021·Journal of Clinical Medicine·Gema Miñana, Julio Núñez
Aug 20, 2021·Frontiers in Cardiovascular Medicine·Bochra Tourki, Ganesh V Halade

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Methods Mentioned

BETA
biopsies

Software Mentioned

PARADIGM
EchoPAC
SPSS
PARAGON
HF

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