What We Do Not Know about Fungal Cell Adhesion Molecules

Journal of Fungi
Peter N Lipke

Abstract

There has been extensive research on structure and function of fungal cell adhesion molecules, but the most of the work has been about adhesins in Candida albicans and Saccharomyces cerevisiae. These yeasts are members of a single ascomycete order, and adhesion molecules from the six other fungal phyla are only sparsely described in the literature. In these other phyla, most of the research is at the cellular level, rather than at the molecular level, so there has been little characterization of the adhesion molecules themselves. A catalog of known adhesins shows some common features: high Ser/Thr content, tandem repeats, N- and O-glycosylations, GPI anchors, dibasic sequence motifs, and potential amyloid-forming sequences. However, none of these features is universal. Known ligands include proteins and glycans on homologous cells and host cells. Existing and novel tools can exploit the availability of genome sequences to identify and characterize new fungal adhesins. These include bioinformatics tools and well-established yeast surface display models, which could be coupled with an adhesion substrate array. Thus, new knowledge could be exploited to answer key questions in fungal ecology, animal and plant pathogenesis, and role...Continue Reading

References

Apr 20, 1999·The Journal of Experimental Medicine·T T BrandhorstB Klein
Apr 27, 2000·Journal of Bacteriology·P Watnick, R Kolter
Nov 29, 2002·Eukaryotic Cell·Mingliang ZhangScott E Erdman
Nov 29, 2002·Eukaryotic Cell·Chong K Jue, Peter N Lipke
Mar 25, 2004·Infection and Immunity·Stephen A KlotzPeter N Lipke
May 7, 2004·The Journal of Biological Chemistry·Donald C SheppardJohn E Edwards
Sep 14, 2004·Nature Biotechnology·Ana-Maria Fernandez-EscamillaLuis Serrano
Jun 25, 2005·Protein Engineering, Design & Selection : PEDS·Z WangD M Neville
Aug 9, 2005·Nature Genetics·Kevin J VerstrepenGerald R Fink
Dec 6, 2005·Journal of Industrial Microbiology & Biotechnology·Michelle E RauchMorley O Stone
Jan 26, 2006·Current Opinion in Structural Biology·Frederic RousseauLuis Serrano
Feb 24, 2006·The Journal of Biological Chemistry·Margit EckerWidmar Tanner
Jul 15, 2006·PLoS Pathogens·Clarissa J NobileAaron P Mitchell
Jul 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Manuel FidalgoJuan Jimenez
Oct 13, 2006·Eukaryotic Cell·Clarissa J NobileAaron P Mitchell
Nov 30, 2006·Antimicrobial Agents and Chemotherapy·Jeniel NettDavid Andes
May 16, 2007·Current Biology : CB·Clarissa J Nobile, Aaron P Mitchell
Jun 8, 2007·Microbiology and Molecular Biology Reviews : MMBR·Anne M DranginisPeter N Lipke
Jul 13, 2007·Current Opinion in Genetics & Development·Malcolm S Steinberg
Sep 18, 2007·Fungal Genetics and Biology : FG & B·Tomas Linder, Claes M Gustafsson
Oct 24, 2007·Eukaryotic Cell·Juan E CoronadoPeter N Lipke
Jul 19, 2008·Current Biology : CB·Clarissa J NobileAaron P Mitchell
Jul 25, 2008·Medical Mycology·Guy TronchinJean-Philippe Bouchara
Sep 6, 2008·Microbiology and Molecular Biology Reviews : MMBR·W LaJean Chaffin
Aug 19, 2009·Proteomics·Rafael Prados-RosalesAntonio Di Pietro
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Lukasz GoldschmidtDavid Eisenberg

❮ Previous
Next ❯

Citations

Aug 1, 2018·Journal of Fungi·Emma Camacho, Arturo Casadevall
Jul 23, 2019·Environmental Microbiology·Mohamed I Abdelwahab HassanMarc Thilo Figge
Jun 23, 2020·Future Medicinal Chemistry·Harlei MartinTrinidad Velasco-Torrijos
Nov 15, 2018·Frontiers in Microbiology·Michael KockLars-Oliver Essen
Dec 14, 2018·Frontiers in Genetics·Beatrice BernardiJürgen Wendland
Aug 11, 2020·World Journal of Microbiology & Biotechnology·Giacomo ZaraSeverino Zara
Jan 29, 2020·Medical Mycology·Lívia S RamosAndré L S Santos
Oct 10, 2020·Biological Chemistry·Lars-Oliver EssenHans-Ulrich Mösch
Jan 31, 2021·Research in Microbiology·Thierry MourerSophie Bachellier-Bassi
Oct 2, 2021·Applied Microbiology and Biotechnology·Yanfang WangJan Dirk van Elsas

❮ Previous
Next ❯

Methods Mentioned

BETA
transglycosylation
AFM
chip

Software Mentioned

TANGO
ConSurf
BLAST
BLAST Search
Fungal
FungalRV

Related Concepts

Related Feeds

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.