What we know about the generation of nystagmus and other ocular oscillations: are we closer to identifying therapeutic targets?

Current Neurology and Neuroscience Reports
R J McLeanFrank Proudlock

Abstract

Mechanisms underlying acquired nystagmus are better understood than those leading to infantile nystagmus. Accordingly, further progress has been made in the development of effective therapies for acquired nystagmus, mainly through pharmacological interventions. Some of these therapies have been developed under the guidance of findings from experimental animal models. Although mechanisms behind infantile nystagmus are less understood, progress has been made in determining the genetic basis of nystagmus and characterizing associated sensory deficits. Pharmacological, surgical, and other treatments options for infantile nystagmus are now emerging. Further investigations are required for all forms of nystagmus to produce high-quality evidence, such as randomized controlled trials, upon which clinicians can make appropriate treatment decisions.

References

Nov 21, 1975·Documenta Ophthalmologica. Advances in Ophthalmology·L F Dell'Osso, R B Daroff
Nov 1, 1992·Annals of Neurology·R J LeighL F Dell'Osso
Jun 1, 1992·Vision Research·H P GoldsteinM G Fendick
Feb 1, 1991·Archives of Ophthalmology·G K von Noorden, D T Sprunger
Jan 1, 1989·Vision Research·R V Abadi, R Worfolk
Jan 1, 1988·Advances in Oto-rhino-laryngology·T UemuraT Hirano
Jan 1, 1987·Movement Disorders : Official Journal of the Movement Disorder Society·B JabbariW McClintock
Nov 1, 1984·The British Journal of Ophthalmology·L B NelsonM S Keisler
Dec 1, 1983·The British Journal of Ophthalmology·E D Allen, P D Davies
Jan 1, 1984·Biological cybernetics·L M Optican, D S Zee
Oct 1, 1981·Journal of Neurophysiology·D S ZeeG Gücer
Jan 1, 1980·The British Journal of Ophthalmology·R V AbadiJ Simpson
Apr 1, 1995·American Journal of Ophthalmology·R L TomsakR J Leigh
Oct 1, 1994·Archives of Ophthalmology·M X RepkaR D Reinecke
Mar 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·J J Barton, T A Cox
Apr 1, 1996·Brain : a Journal of Neurology·L I LopezP Rudge
Jan 1, 1997·Journal of Neurology·M StarckM Dieterich
Mar 31, 1999·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·J J BartonK B Digre
Sep 5, 1994·Current Opinion in Ophthalmology·A Spielmann
Jul 9, 1999·Eye·H AtillaY Işikçelik
Nov 30, 2000·Survey of Ophthalmology·R W Hertle
Aug 3, 2001·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M GräfH Kaufmann
Apr 19, 2002·Annals of the New York Academy of Sciences·R John LeighScott H Seidman
Apr 19, 2002·Annals of the New York Academy of Sciences·David SolomonAnupam Mishra
May 2, 2002·Journal of the Royal Society of Medicine·Richard V Abadi
Jun 22, 2002·Documenta Ophthalmologica. Advances in Ophthalmology·L F Dell'Osso, J B Jacobs
Sep 18, 2002·The British Journal of Ophthalmology·R V Abadi, A Bjerre
Nov 14, 2002·American Journal of Ophthalmology·Sunila JainIrene Gottlob
Dec 24, 2004·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Richard W HertleSusan D Mellow
Feb 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·S GlasauerT Brandt
May 6, 2005·Brain : a Journal of Neurology·C Pierrot-Deseilligny, D Milea
Mar 25, 2006·The British Journal of Ophthalmology·T SheryI Gottlob
May 17, 2006·Seminars in Ophthalmology·Chris Harris, David Berry
May 30, 2006·Journal of Computational Neuroscience·O E AkmanR V Abadi

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Citations

Mar 7, 2013·Ophthalmology·Niraj BarotFrank A Proudlock

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