What we learn from transformation suppressor genes: lessons from RECK

Future Oncology
Makoto NodaHitoshi Kitayama

Abstract

Expression cloning is a powerful approach to finding genes that induce appreciable changes in cultured cells. One way to use this technique in cancer research is to isolate cDNAs that induce flat reversion in transformed cells. Such screening, however, is inherently artificial, and therefore requires independent validation of the clinical relevance of isolated genes. Studies of the mechanisms of actions, physiological functions and mechanisms of regulation of these genes at various levels may enrich our knowledge of cancer biology and supplement our toolbox in developing new cancer diagnoses and therapies. In this article we discuss the promise, limitations and recent innovations in this approach, taking one transformation suppressor gene, RECK, as an example.

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Citations

Mar 16, 2012·International Journal of Biological Sciences·Changsong ZhangLixin Wei
Nov 28, 2012·Cellular and Molecular Life Sciences : CMLS·Marilyne Labrie, Yves St-Pierre
Mar 5, 2016·Cancer Science·Makoto NodaCalvin J Kuo
Oct 25, 2017·Journal of Cellular Biochemistry·Yuan LiuHongjuan Song

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Methods Mentioned

BETA
transfection
zymography
two-hybrid
pull-down
Glycosylation

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