What, When, and How of Biomarker Testing in Non-Small Cell Lung Cancer

Journal of the National Comprehensive Cancer Network : JNCCN
Gregory L Riely

Abstract

Biomarker testing is recommended for all patients diagnosed with non-small cell lung cancer. At a minimum, testing should include the mutations/fusions EGFR, ALK, ROS1, and the protein programmed death ligand-1 (PD-L1), because FDA-approved therapies are available for these alterations. Other actionable molecular findings include RET rearrangements, BRAFV600E mutations, and MET exon 14 alterations. If adequate testing was not performed at treatment initiation, molecular testing should be performed before administration of subsequent lines of therapy. In patients with EGFR-mutant lung cancer, when resistance develops, physicians should seek to identify the T790M mutation using plasma and tissue assays, because osimertinib therapy is available for this mutation.

Citations

Sep 13, 2019·Expert Review of Respiratory Medicine·Antonio Rossi
Feb 20, 2020·Expert Opinion on Investigational Drugs·Umberto MalapelleAntonio Rossi
Feb 23, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lauren L PalazzoChung Yin Kong

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