What will my child's future hold? phenotypes of intellectual development in 2-8-year-olds with autism spectrum disorder.

Autism Research : Official Journal of the International Society for Autism Research
Marjorie SolomonDavid G Amaral

Abstract

We examined phenotypes of autism spectrum disorder (ASD) based on trajectories of intellectual development from early (ages 2-3 ½) to middle (ages 5-8) childhood in a recent clinically ascertained cohort. Participants included 102 children (82 males) initially diagnosed with ASD from the Autism Phenome Project longitudinal sample. Latent class growth analysis was used to identify distinct IQ trajectories. Baseline and developmental course differences among groups were assessed using univariate techniques and repeated measures regression models, respectively. A four class model best represented the data. Using the highest posterior probability, participants were assigned to High Challenges (25.5%), Stable Low (17.6%), Changers (35.3%), and Lesser Challenges (21.6%) groups. The High Challenges and Stable Low groups exhibited persistently low IQ, although, the High Challenges group experienced declines while the Stable Low group's scores remained more constant. Changers showed IQ improvement of > 2 standard deviations. The Lesser Challenges group had IQs in the average range at both times that were about 1 standard deviation higher at T2. In summation, 75% of the participants experienced some relative improvements in intellectual ...Continue Reading

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Citations

Apr 27, 2019·Autism Research : Official Journal of the International Society for Autism Research·David G AmaralAndrew Whitehouse
Oct 28, 2019·Autism : the International Journal of Research and Practice·Elizabeth C BaconKaren Pierce
Apr 24, 2020·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Anat Zaidman-ZaitMayada Elsabbagh
Dec 4, 2019·Autism Research : Official Journal of the International Society for Autism Research·Sachie KanekoToshifumi Kishimoto
May 16, 2020·Journal of Autism and Developmental Disorders·Einat Waizbard-BartovDavid G Amaral
Dec 31, 2020·International Journal of Environmental Research and Public Health·Dominique H ComoSharon A Cermak
May 4, 2021·Child Psychiatry and Human Development·Kenzie B BilleiterDaniel B Hajovsky
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Jun 6, 2021·Journal of Autism and Developmental Disorders·Serene HabayebAllison Ratto
Aug 10, 2021·The Clinical Neuropsychologist·Louise C P Fennell, Shannon A Johnson

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