What's Hot in HIV in 2019-A Basic and Translational Science Summary for Clinicians From IDWeek 2019

Open Forum Infectious Diseases
Boghuma Titanji, Colleen F Kelley

Abstract

The field of HIV research is constantly evolving, and every year brings advances that draw us closer to ending the HIV epidemic. Here, we present a nonexhaustive overview of select notable studies in HIV prevention, cure, and treatment, published in the last year as presented at IDWeek 2019: What's Hot in HIV Basic Science. The past year brought interesting results on the use of broadly neutralizing antibodies for treatment and prevention, gene-editing approaches to HIV cure, and new ways to measure the HIV reservoir. We also saw encouraging results on novel HIV vaccine delivery strategies and how these may influence effective immune responses. Lastly, in the area of inflammation, some mechanistic insights were made into the contribution of cotrimoxazole prophylaxis and potential new targets to reduce HIV-associated chronic inflammation. The future from where we stand is bright for HIV research, with much more to look forward to in 2020.

References

Sep 29, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Nia Tatsis, Hildegund C J Ertl
Jan 22, 2005·Critical Reviews in Therapeutic Drug Carrier Systems·Rajan K VermaSanjay Garg
Oct 22, 2009·The New England Journal of Medicine·Supachai Rerks-NgarmUNKNOWN MOPH-TAVEG Investigators
Nov 16, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Theodoros KelesidisSotirios Tsiodras
Jan 28, 2017·Expert Opinion on Drug Delivery·Benson EdagwaHoward E Gendelman
Dec 23, 2017·Retrovirology·Nicholas J NortonAndrew M L Lever
Mar 4, 2018·Current HIV/AIDS Reports·Thor A Wagner
Apr 19, 2018·Current Pharmaceutical Biotechnology·Androulla N Miliotou, Lefkothea C Papadopoulou
Apr 20, 2018·International Journal of Molecular Sciences·Maria TrovatoPiergiuseppe De Berardinis
Jun 13, 2018·The Lancet. HIV·Matthew C PitmanSharon R Lewin
Aug 14, 2018·Clinical Pharmacology and Therapeutics·Harriet L Robinson
Aug 16, 2018·The New England Journal of Medicine·Brinda EmuStanley Lewis
Sep 28, 2018·Nature·Pilar MendozaMichel C Nussenzweig
Oct 23, 2018·Therapeutic Advances in Vaccines and Immunotherapy·Rajesh KumarJayanta Bhattacharya
Jan 29, 2019·The Journal of Clinical Investigation·Kevin B EinkaufMathias Lichterfeld
Apr 5, 2019·Science Translational Medicine·Claire D BourkeAndrew J Prendergast
Apr 18, 2019·The New England Journal of Medicine·Chang-Yi WangMei-June Liao
Jul 4, 2019·Nature Communications·Prasanta K DashHoward E Gendelman
Jul 28, 2019·The Journal of Experimental Medicine·Christian GaeblerMichel C Nussenzweig
Jul 31, 2019·The Journal of Clinical Investigation·William R McManusMary F Kearney
Aug 20, 2019·Nature Communications·Carla Serra-PeinadoMaria J Buzon
Sep 12, 2019·The New England Journal of Medicine·Lei XuHu Chen
Jan 25, 2020·Journal of the American Heart Association·Boghuma TitanjiVincent C Marconi

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Methods Mentioned

BETA
DNA assay
PCR

Software Mentioned

IPDA

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