What's in a name? That which we call Multiple Sclerosis Fatigue.

Multiple Sclerosis : Clinical and Laboratory Research
Amy Lynn HubbardHedda Lausberg

Abstract

Very limited progress has been made to date in the treatment of debilitating Multiple Sclerosis (MS) daily onset symptoms. These daily symptoms include motor, sensory, and cognitive impairments as well as an overwhelming feeling of tiredness, often referred to as "MS fatigue." Although widely cited as a main cause of inability to work and poor quality of life in patients with MS, daily onset MS-related tiredness continues to defy definition, and, consequently, measurement and treatment. Beginning with a historical overview of observations of daily onset MS-related tiredness, this Topical Review demonstrates how the misnomer "MS fatigue" has introduced ongoing misunderstanding for patients, investigators, clinicians, and therapists. Finally, combining current findings in clinical neuroscience with the striking set of long-standing commonalities present throughout the past 200 years of clinical observations, we underscore the immediate necessity for conceptual and applied change, to be initiated by the renaming of this distinct syndrome.

References

Apr 1, 1988·Archives of Neurology·L B KruppL C Scheinberg
Aug 1, 1985·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·T J Murray
Mar 1, 1995·Journal of the Neurological Sciences·T C Guthrie, D A Nelson
Jan 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J D FiskW F Schlech
Apr 25, 2000·Multiple Sclerosis : Clinical and Laboratory Research·D C KroenckeD R Denney
Dec 20, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·G Giovannoni
Jan 16, 2008·QJM : Monthly Journal of the Association of Physicians·R J Mills, C A Young
Oct 20, 2009·Clinical Neurology and Neurosurgery·Edward T LittletonJacqueline Palace
Dec 10, 2009·Multiple Sclerosis : Clinical and Laboratory Research·I K PennerP Calabrese
Jan 8, 2011·Nursing & Health Sciences·Rika Moriya, Masami Kutsumi
Oct 28, 2011·Journal of Neuroengineering and Rehabilitation·Aida SehleManfred Vieten
Mar 20, 2012·Expert Opinion on Pharmacotherapy·Friedemann Paul, Christian Veauthier
Feb 25, 2014·Archives of Physical Medicine and Rehabilitation·James F Sumowski, Victoria M Leavitt
Oct 26, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Anat AchironYoram Barak
Dec 7, 2018·Lancet Neurology·Catherine Lubetzki

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Citations

Sep 30, 2021·Neurorehabilitation and Neural Repair·Roger M EnokaJacques Duchateau

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