What's new in atopic eczema? An analysis of systematic reviews published in 2008 and 2009

Clinical and Experimental Dermatology
J M BatchelorH C Williams

Abstract

This review summarizes clinically important findings from nine systematic reviews of the causes, treatment and prevention of atopic eczema (AE) published between August 2008 and August 2009. Two systematic reviews concluded that there is a strong and consistent association between filaggrin (FLG) mutations and development of eczema. The associations between FLG mutations and atopic sensitization, rhinitis and asthma are weaker than between FLG mutations and eczema, especially if those who also have eczema are excluded. The relationship between transforming growth factor levels in breast milk and eczema development is still unclear. A further systematic review found no strong evidence of a protective effect of exclusive breastfeeding for at least 3 months against eczema, even in those with a positive family history of atopy. Based on a systematic review and meta-analysis of six randomized controlled trials, supplementation with omega-3 and omega-6 oils is unlikely to play an important role in the primary prevention of eczema or allergic diseases in general. There is little evidence to support dietary restrictions of certain foods in unselected children with AE. There is also little evidence to suggest a clinically useful benefit...Continue Reading

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Citations

May 18, 2013·Journal of the American Academy of Dermatology·Howard B PrideRobert Silverman
Mar 14, 2012·The Journal of Allergy and Clinical Immunology·Ting Seng TangHywel C Williams
Mar 23, 2011·The Journal of Allergy and Clinical Immunology·Emma Guttman-YasskyJames G Krueger
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Jul 2, 2011·Clinical and Experimental Dermatology·K ShamsH C Williams
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Mar 17, 2020·The Cochrane Database of Systematic Reviews·Zhirong YangQian Zhang
Jun 12, 2013·Clinical and Experimental Dermatology·D TorleyK S Thomas

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