What's New in Dermatological Therapy?

Annales de dermatologie et de vénéréologie
H Bachelez

Abstract

During the ongoing year were published results from clinical trials opening new perspectives in the treatment of chronic inflammatory and dysimmune skin diseases. If this therapeutic development still predominantly on moderate-to- severe forms of plaque psoriasis, it tends to be more diversified towards moderate-to- severe forms of other diseases heavily impacting on patients'lives such as atopic dermatitis in adulthood, and hidradenitis suppurativa. Likewise, the development of IL-17 and IL-23 biological inhibitors, but also of small molecules such as tofacitinib in psoriasis, and the achievement of dupilumab phase 2 studies in atopic dermatitis provide evidence for the high efficacy of these therapies, while adalimumab is the first drug to be approved for the treatment of hidradenitis suppurativa. On the other hand, advances in vaccinology allowed the successful development of innovative vaccine respectively against Herpes zoster and 9 serotypes of human papillomavirus. For all these interventions, prolonged real-life pharmacovigilance will be necessary to provide a more accurate picture of their respective benefit-to- risk balances.

References

Feb 19, 2015·The New England Journal of Medicine·Elmar A JouraUNKNOWN Broad Spectrum HPV Vaccine Study
Mar 11, 2015·Nature·Tamara KoppSauzanne Khalilieh
Apr 29, 2015·The New England Journal of Medicine·Himal LalUNKNOWN ZOE-50 Study Group
Apr 29, 2015·The New England Journal of Medicine·Jeffrey I Cohen
May 15, 2015·The New England Journal of Medicine·Lisa Rosenbaum
Jun 9, 2015·Lancet·Mark Lebwohl
Jul 15, 2015·The New England Journal of Medicine·Kenneth B GordonKristian Reich
Oct 1, 2015·The New England Journal of Medicine·Mark LebwohlAjay Nirula
Oct 1, 2015·The New England Journal of Medicine·Philip J MeaseUNKNOWN FUTURE 1 Study Group

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Citations

Jul 24, 2015·The British Journal of Dermatology·D Wallach, M-D Vignon-Pennamen
Feb 21, 2018·Journal of the Chinese Medical Association : JCMA·Ying-Xiu DaiYun-Ting Chang

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