What's new in the IGF-binding proteins?

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
Steven A Rosenzweig

Abstract

Since their initial discovery over 25 years ago as IGF carrier proteins, the insulin-like growth factor binding protein (IGFBP) family has grown to six members, ranging in size from 216 to 289 amino acids. The assumption over the years has been that this family of proteins, having higher affinities for IGF-I and IGF-II than does the IGF-IR, serves to block access of these ligands to the receptor. Although the need for such regulatory proteins is consistent with the constitutive secretion of IGFs from many cell types, it is not surprising that additional functions have begun to be uncovered for these proteins. This review will examine new and old actions of the IGFBPs from a biochemical and cell biological perspective.

References

Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J I JonesD R Clemmons
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·S A LoddickE B De Souza
Apr 29, 1998·The Journal of Clinical Endocrinology and Metabolism·P VorwerkR G Rosenfeld
Aug 29, 1998·The Journal of Biological Chemistry·X QinS Mohan
Oct 21, 1999·Journal of the National Cancer Institute·L BubendorfO P Kallioniemi
Dec 22, 1999·Endocrine Reviews·V HwaR G Rosenfeld
Apr 1, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M R SchneiderE Wolf
May 16, 2000·The Journal of Biological Chemistry·L J SchedlichR C Baxter
May 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·R C Baxter
Jan 3, 2001·The Journal of Clinical Investigation·N MiyakoshiS Mohan
Jul 7, 2001·American Journal of Physiology. Endocrinology and Metabolism·D L Andress
Oct 16, 2001·The Journal of Clinical Endocrinology and Metabolism·C K BuckwayR G Rosenfeld

❮ Previous
Next ❯

Citations

Aug 30, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Pin LuDavid J Harrison
Mar 21, 2006·Annals of Biomedical Engineering·Julie M D Paye, Kimberly Forsten-Williams
Nov 21, 2009·Human Reproduction Update·K G PringleC T Roberts
Feb 12, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shuzhen ZhuMaode Lai
Sep 10, 2005·Proceedings of the National Academy of Sciences of the United States of America·Andrew SawczenkoIan R Sanderson
Jul 6, 2010·Biochemical Pharmacology·Steven A Rosenzweig, Hanudatta S Atreya
May 25, 2010·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Zhongquan DaiYinghui Li
Apr 14, 2005·Domestic Animal Endocrinology·Brian C Peterson, Brian C Small
Jun 15, 2010·Archives of Biochemistry and Biophysics·Monalisa SwainHanudatta S Atreya
Feb 28, 2006·Biochemical and Biophysical Research Communications·Mark G SlomianySteven A Rosenzweig
Sep 27, 2005·Bone·Melanie C FisherCaroline N Dealy
Jun 21, 2005·Mechanisms of Ageing and Development·M E LemieuxM W McBurney
Jan 16, 2010·Cell Metabolism·Kristina HedbackerJeffrey M Friedman
Dec 3, 2014·Protein Expression and Purification·Anne Sofie Molsted WanscherGiuseppe Cazzamali
Jun 22, 2006·American Journal of Physiology. Endocrinology and Metabolism·Oren FroyRuth Miskin
May 10, 2006·The Journal of Pharmacology and Experimental Therapeutics·Mark G Slomiany, Steven A Rosenzweig
Jan 23, 2008·Clinical Science·Mikael LehtihetKerstin Brismar
Apr 1, 2020·F1000Research·Steven A Rosenzweig
Nov 1, 2011·Revista Brasileira De Ortopedia·Alessandra Deise SebbenJefferson Luis Braga da Silva
May 3, 2008·Cancer Research·Brent W SutherlandNorman M Greenberg
Jul 3, 2021·Cells·Marina CaputoFlavia Prodam
Dec 25, 2019·Experimental and Molecular Pathology·Gurjeet KaurYung Jen Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.