What's New in the Treatment of Urticaria and Angioedema.

The Journal of Allergy and Clinical Immunology. in Practice
David A KhanEmel Aygören-Pürsün

Abstract

Chronic urticaria and angioedema are diseases often managed by Allergy and Immunology specialists. Recent international guidelines have outlined a stepwise approach to management of patients using dose escalation of second-generation antihistamines followed by use of omalizumab and finally cyclosporine in more refractory cases. In select patients (those with refractory chronic urticaria), nonbiologic alternative medications with anti-inflammatory or immunosuppressant activity may be considered. Angioedema without wheals may have several different pathophysiologic mechanisms. Optimal management of mast cell-mediated angioedema is less clear but is often managed similar to chronic spontaneous urticaria. Drug-induced angioedema due to angiotensin-converting enzyme inhibitors is a common cause of angioedema in the emergency department. Although bradykinin is thought to be a primary mediator for this type of angioedema, studies of targeted therapies have been generally disappointing. In contrast, several targeted therapies have been proven successful using acute and preventive approaches for management of hereditary angioedema. Further developments, including novel biologics, novel oral therapies, and gene therapy approaches, may ho...Continue Reading

References

Nov 1, 1986·The Journal of Allergy and Clinical Immunology·A B GoldsobelR J Barr
Jul 6, 2000·Immunopharmacology·S Matsuda, S Koyasu
Aug 22, 2000·The British Journal of Dermatology·C E GrattanM W Greaves
Nov 13, 2001·American Journal of Respiratory and Critical Care Medicine·E S Schulman
Nov 19, 2004·The New England Journal of Medicine·F Estelle R Simons
Nov 7, 2006·Immunology and Allergy Clinics of North America·James Brian ByrdNancy J Brown
Jun 4, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Matt Morgan, David A Khan
Jul 3, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Matt Morgan, David A Khan
Nov 12, 2009·The British Journal of Dermatology·A PerezC E H Grattan
Jan 23, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Michael DuerrKlemens Budde
Feb 12, 2010·Allergy·M K ChurchUNKNOWN Global Allergy and Asthma European Network
Sep 8, 2010·The New England Journal of Medicine·Bruce L ZurawMichael M Frank
Jun 4, 2011·The Journal of Allergy and Clinical Immunology·Marcus MaurerPetra Staubach
Jul 26, 2011·Journal of the American Academy of Dermatology·Andrew B ZimmermanNicholas A Soter
Mar 30, 2012·Current Medical Research and Opinion·K YanaiR Boev
Apr 24, 2012·The American Journal of Cardiology·Harikrishna MakaniSripal Bangalore
Jul 18, 2012·The American Journal of Medicine·Bruce L Zuraw, Ira Kalfus
Feb 26, 2013·The New England Journal of Medicine·Marcus MaurerThomas Casale
Jul 3, 2013·The Journal of Allergy and Clinical Immunology·Allen KaplanKarin Rosén
Nov 26, 2013·Allergy and Asthma Proceedings·Teresa CaballeroHenrik B Boysen
Dec 18, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Roy Anthony OrdenSarbjit S Saini
Feb 11, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Andy RorieJill A Poole
Feb 26, 2014·The Journal of Allergy and Clinical Immunology. in Practice·David A Khan
Apr 29, 2014·The Journal of Allergy and Clinical Immunology·Jonathan A BernsteinDana Wallace
Jun 10, 2014·Allergy·A MuraroUNKNOWN EAACI Food Allergy and Anaphylaxis Guidelines Group
Jul 6, 2014·Orphanet Journal of Rare Diseases·Emel Aygören-PürsünTeresa Caballero
Sep 13, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Matt MorganDavid A Khan
Jan 21, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jonathan A BernsteinChris J Lindsell
Jan 30, 2015·The New England Journal of Medicine·Murat BaşThomas K Hoffmann
Feb 11, 2015·Internal and Emergency Medicine·Maria BovaAndrea Zanichelli
Feb 26, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R J PowellA T Clark
Oct 21, 2015·The Journal of Allergy and Clinical Immunology·Allen KaplanJames L Zazzali
Feb 20, 2016·Journal of the American Academy of Dermatology·François AubinUNKNOWN Société Française de Photodermatologie
May 21, 2016·Stroke; a Journal of Cerebral Circulation·Fjorda MyslimiDidier Leys

❮ Previous
Next ❯

Citations

Jun 12, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Marc Riedl, Marcus Maurer
Aug 28, 2021·International Journal of Molecular Sciences·Akane WadaMotonobu Nakamura

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

The Journal of Allergy and Clinical Immunology
K P Mathews
Advances in Dermatology
J J Green, W R Heymann
New York State Journal of Medicine
A D SPIELMAN
Journal of the Mississippi State Medical Association
B Booth
Clinical Reviews in Allergy
B A Burrall, A C Huntley
© 2021 Meta ULC. All rights reserved