PMID: 22580517May 15, 2012Paper

What's the role of topiramate in the management of patients with hyperkinetic movement disorders?

Pharmacological Reports : PR
Antonio SiniscalchiGiovambattista De Sarro

Abstract

Topiramate (TPM) is an O-alkyl sulfamate derivative of the naturally occurring monosaccharide D-fructose with an epileptic activity. However, it has been suggested that, in addition to its use in epilepsy, TPM could also be used in the treatment of neurological disorders, psychiatric conditions and hyperkinetic movement disorders. The clinical applications of TPM in hyperkinetic movement disorders is consistent with the multiple pharmacodynamic mechanisms e.g., the modulation of both γ-aminobutyric acidergic or glutamatergic neurotransmission and the modulation of voltage-gated ion channels or intracellular signalling pathways. The purpose of the present review is to describe the mechanisms of action of TPM and its clinical efficacy in patients with hyperkinetic movement disorders.

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Citations

Jan 5, 2013·Clinical Drug Investigation·Antonio SiniscalchiGiovambattista De Sarro
Dec 21, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Emilio RussoGiovambattista De Sarro
Aug 13, 2014·BioMed Research International·Domenico PirritanoGiovambattista De Sarro
Sep 21, 2013·European Journal of Pharmacology·Antonio SiniscalchiGiovambattista De Sarro
Jan 9, 2014·Pharmacological Reports : PR·Bogusława PietrzakJakub Wojcieszak

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