PMID: 2506263Sep 1, 1989Paper

Wheal-and-flare responses to intradermally injected adenosine 5'-monophosphate, hypertonic saline, and histamine: comparison of atopic and nonatopic subjects

The Journal of Allergy and Clinical Immunology
R DjukanovicS T Holgate

Abstract

Adenosine 5'-monophosphate (AMP) in increasing concentrations, and saline solutions of corresponding tonicity, were injected intradermally in seven atopic and seven normal subjects. Skin wheal-and-flare responses were elicited in a dose-dependent fashion in all subjects, and no difference was found between responses produced by AMP and responses produced by saline of corresponding tonicity. Also, no difference in response to AMP and saline was found between atopic and nonatopic subjects. We further investigated, in seven atopic subjects, whether the skin wheal-and-flare response to the single, highest dose of AMP, saline, and histamine could be inhibited by preadministration of 180 mg of terfenadine, a potent H1 antagonist. A significant inhibition of the wheal-and-flare response to histamine and no significant inhibition to AMP were found. There was a significant inhibition of the flare response caused by hypertonic saline but no inhibition of the wheal response. We interpret these findings as indicating that AMP does not specifically lead to mast cell degranulation in the skin and that there are functional differences between cutaneous and lung mast cells. The observation that terfenadine significantly inhibited the flare res...Continue Reading

Citations

Jul 1, 1995·British Journal of Clinical Pharmacology·A M ShararaP W Ind
Jan 31, 2002·American Journal of Respiratory and Critical Care Medicine·Stephen T Holgate
Aug 1, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Haruhisa NishiEdward S Schulman

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