Wheat germ policosanol failed to lower plasma cholesterol in subjects with normal to mildly elevated cholesterol concentrations

Metabolism: Clinical and Experimental
Yuguang LinGert W Meijer

Abstract

Sugar cane policosanol, a mixture of long-chain primary alcohols (approximately 67% as octacosanol), has been reported to lower plasma low-density lipoprotein (LDL)-cholesterol. We investigated the effect of wheat germ policosanol (WGP) on plasma lipid profiles in 58 adults (30 men and 28 women, aged 49 +/- 11 years) with normal to mildly elevated plasma cholesterol concentrations in a double-blind, randomized, parallel placebo-controlled study. Subjects consumed chocolate pellets with or without 20 mg/d WGP for 4 weeks. Plasma lipid concentrations, routine blood chemistry and hematology were determined at the start and the end of the study. The initial plasma total, LDL-cholesterol, high-density lipoprotein (HDL)-cholesterol, and triacylglycerol concentrations in the WGP and the control groups were identical. Over the 4 weeks, neither the WGP nor the control treatment significantly changed plasma total cholesterol, LDL- and HDL-cholesterol, or triacylglycerol concentrations when compared to baseline values. In addition, there was no significant difference in plasma lipid profiles between the WGP and the control groups at the end of the study. WGP did not result in any adverse effects as indicated by plasma activities of L-gamm...Continue Reading

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Citations

Nov 4, 2008·Journal of the American College of Nutrition·Karen J MurphyPeter R C Howe
Sep 8, 2011·Journal of the American College of Nutrition·Qun LiMichael T Clandinin
Mar 20, 2010·Critical Reviews in Food Science and Nutrition·Christopher P F MarinangeliMichael N A Eskin
Jul 19, 2012·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·David D KittsDavid G Popovich
May 2, 2008·Lipids in Health and Disease·Amira N Kassis, Peter J H Jones
Aug 2, 2011·The Canadian Journal of Cardiology·Jingbo HuangAndrew P Ignaszewski
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Nov 25, 2006·Atherosclerosis·Amira N KassisPeter J H Jones
Jan 2, 2008·Phytotherapy Research : PTR·F Francini-PesentiF Brocadello
Jan 31, 2017·Nature Reviews. Endocrinology·Paola M Hunter, Robert A Hegele
Oct 19, 2006·The Annals of Pharmacotherapy·Leslie K NiesKari L Olson
Sep 13, 2014·Journal of the Science of Food and Agriculture·Hajer TrabelsiPaul Mayer
Feb 15, 2007·The British Journal of Nutrition·Christopher P F MarinangeliPeter J H Jones
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Sep 10, 2008·Journal of Agricultural and Food Chemistry·Zhen-Yu ChenKa Ying Ma

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