Wheat microbiome bacteria can reduce virulence of a plant pathogenic fungus by altering histone acetylation

Nature Communications
Yun ChenZhonghua Ma

Abstract

Interactions between bacteria and fungi have great environmental, medical, and agricultural importance, but the molecular mechanisms are largely unknown. Here, we study the interactions between the bacterium Pseudomonas piscium, from the wheat head microbiome, and the plant pathogenic fungus Fusarium graminearum. We show that a compound secreted by the bacteria (phenazine-1-carboxamide) directly affects the activity of fungal protein FgGcn5, a histone acetyltransferase of the SAGA complex. This leads to deregulation of histone acetylation at H2BK11, H3K14, H3K18, and H3K27 in F. graminearum, as well as suppression of fungal growth, virulence, and mycotoxin biosynthesis. Therefore, an antagonistic bacterium can inhibit growth and virulence of a plant pathogenic fungus by manipulating fungal histone modification.

References

Jun 22, 2002·Science·Deborah A Hogan, Roberto Kolter
Nov 9, 2002·Molecular Plant-microbe Interactions : MPMI·Henk-jan SchoonbeekMaarten A De Waard
Jan 7, 2003·Applied and Environmental Microbiology·Andrew J McBainPeter Gilbert
Jun 7, 2003·Molecular Microbiology·Mikkel KlausenTim Tolker-Nielsen
Jul 15, 2003·Clinical Microbiology Reviews·J W Bennett, M Klich
Aug 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Chad W Saltikov, Dianne K Newman
Nov 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Huimin RanGee W Lau
Mar 11, 2004·Chemical Reviews·Jane Buus Laursen, John Nielsen
Nov 25, 2004·Molecular Plant-microbe Interactions : MPMI·Alexander SchoutenJos M Raaijmakers
Jan 11, 2005·Trends in Microbiology·Steven S BrandaRoberto Kolter
Jan 6, 2006·Molecular Biology of the Cell·Shaojie LiSteven D Harris
May 25, 2006·Annual Review of Phytopathology·Dmitri V MavrodiLinda S Thomashow
Jun 17, 2006·Current Opinion in Microbiology·Matthew J Wargo, Deborah A Hogan
Sep 7, 2007·The New Phytologist·P Frey-KlettM Tarkka
Oct 17, 2007·Annual Review of Medicine·A Simon Lynch, Gregory T Robertson
Aug 12, 2008·Cell Host & Microbe·Mélanie Anne Hamon, Pascale Cossart
Aug 7, 2009·Molecular Plant-microbe Interactions : MPMI·Yan-Jun ZhangMing-Guo Zhou
Jul 9, 2010·FEMS Immunology and Medical Microbiology·Brian M PetersMark E Shirtliff
Nov 26, 2010·Current Opinion in Chemical Biology·Cheuk Hei HoCharles Boone
Aug 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Hans-Wilhelm NützmannAxel A Brakhage
Dec 1, 2011·Microbiology and Molecular Biology Reviews : MMBR·P Frey-KlettA Sarniguet
Jan 5, 2012·PLoS Pathogens·Chenfang WangJin-Rong Xu
Apr 5, 2012·Molecular Plant Pathology·Ralph DeanGary D Foster
May 9, 2012·Trends in Plant Science·Roeland L BerendsenPeter A H M Bakker
Jun 2, 2012·Journal of Chemical Ecology·Uta EffmertBirgit Piechulla
Jul 28, 2012·Molecular Plant-microbe Interactions : MPMI·Jon MenkeH Corby Kistler
May 28, 2013·Communicative & Integrative Biology·Theerthankar Das, Mike Manefield
Aug 3, 2013·Science·Haig A EskandarianMélanie A Hamon
May 17, 2014·Molecular Plant Pathology·Qin GuZhonghua Ma
Sep 23, 2014·Fungal Genetics and Biology : FG & B·Juan Manuel González-PrietoJosé Ruiz-Herrera

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Citations

Dec 19, 2018·FEMS Microbiology Ecology·Briana K Whitaker, Matthew G Bakker
Mar 15, 2019·Pest Management Science·Linda S ThomashowDavid M Weller
Oct 9, 2019·Microorganisms·Rosie E BradshawMurray P Cox
Nov 28, 2018·Nature Communications·Irene de Bruijn, Koen J F Verhoeven
Oct 14, 2019·Journal of Applied Microbiology·Yumei DaiTao Wang
Jun 24, 2020·Molecular Plant Pathology·Michael MentgesAna Lilia Martinez-Rocha
Apr 4, 2019·Frontiers in Microbiology·Nandhitha Venkatesh, Nancy P Keller
Dec 21, 2019·Environmental Microbiology Reports·Tao TianYunrong Chai
Aug 27, 2019·Microbial Ecology·Edward C RojasDavid B Collinge
Jul 23, 2020·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Xiaowen SunHong Ni
Sep 5, 2018·Nature Reviews. Microbiology·Ashley York
Nov 30, 2019·Archives of Microbiology·Abhinav AeronRajesh Kumar Meena
Aug 8, 2020·Frontiers in Microbiology·Marie LegeinSarah Lebeer
Jun 14, 2019·PLoS Pathogens·Nathan VannierStéphane Hacquard
Dec 11, 2019·International Journal of Molecular Sciences·Elena Maria ColomboMatias Pasquali
Mar 21, 2019·Annual Review of Phytopathology·Yun ChenZhonghua Ma
Jun 26, 2020·Frontiers in Bioengineering and Biotechnology·Rodrigo Rodriguez, Paola Durán
Dec 12, 2020·Scientific Reports·Feiying ZhuZhihuai Liang
Jan 19, 2021·Microbiological Research·Janie ZhangZhenyu Cheng
May 5, 2021·Plant Biotechnology Journal·Gaetano GiudiceWalter Chitarra
Apr 1, 2021·The Plant Journal : for Cell and Molecular Biology·Hao-Xun ChangMartin I Chilvers
Jun 19, 2021·Annual Review of Plant Biology·Christine V HawkesLars Hestbjerg Hansen
Jun 26, 2021·Scientific Reports·Eman M KhalafManish N Raizada
Jun 26, 2021·Microbial Ecology·José F Cobo-DíazAdeline Picot
Jun 22, 2021·Frontiers in Plant Science·Pengfei Zhi, Cheng Chang
Jul 3, 2021·Journal of Fungi·Lucile PellanSabine Schorr-Galindo

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Methods Mentioned

BETA
histone acetylation
PCA
scanning
transmission electron microscopy
acetylation
surface
biosensor
PCR
column chromatography
chip

Software Mentioned

ImageJ
antiSMASH
Biacore Evaluation
Molecular Evolutionary Genetics Analysis

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