Wheel access does not attenuate weight gain in mice fed high-fat or high-CHO diets.

Medicine and Science in Sports and Exercise
Alan P Jung, David R Luthin

Abstract

To determine the effect of a high-fat or high-carbohydrate diet and running wheel activity on body composition, body mass, and caloric intake in C57Bl/6 mice. At 4 wk of age, five groups of C57Bl/6 mice were housed individually. Two groups had running wheels, whereas the other three groups did not. Within the running wheel groups, FAT-W consumed a high-fat diet (60.3% fat) and CHO-W consumed a high-carbohydrate diet (70.4% carbohydrate). Within the nonrunning groups, FAT consumed the high-fat diet, CHO consumed the high-carbohydrate diet, and the fifth group consumed standard chow. All groups consumed food ad libitum and were exposed to their respective conditions for 12 wk. Wheel activity, food consumption, body mass (BM), and percentage of body fat (%BF) were recorded. There was no significant difference in %BF or BM at the end of 12 wk between FAT-W and FAT or between CHO-W and CHO (P > 0.05). %BF was significantly higher in both FAT-W (42.9% +/- 0.6%) and FAT (45.9% +/- 0.8%) compared with CHO-W (30.8% +/- 1.4%) or CHO (33.4% +/- 1.0%; P < 0.001). BM was significantly higher in both FAT-W (42.8 +/- 0.7 g) and FAT (44.7 +/- 1.2 g) compared with either CHO-W (32.8 +/- 1.6 g) or CHO (37.1 +/- 0.8; P < 0.01). There was no diffe...Continue Reading

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Citations

Mar 11, 2010·Medicine and Science in Sports and Exercise·Alan P JungJ Timothy Lightfoot
Aug 9, 2016·Physiology & Behavior·Francine Pereira de CarvalhoCamila Aparecida Machado de Oliveira
Sep 13, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bo SunKellie L K Tamashiro
Jan 27, 2018·Bioscience Reports·Francine Pereira de CarvalhoCamila Aparecida Machado de Oliveira
Apr 29, 2020·American Journal of Physiology. Endocrinology and Metabolism·Timothy D AllertonJacqueline Stephens
Apr 28, 2019·Physiology & Behavior·Joshua Cordeira, Daniel Monahan

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