Wheezing preschool children with early-onset asthma reveal a specific metabolomic profile

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Silvia CarraroEugenio Baraldi

Abstract

Many children of preschool age present with recurrent wheezing. Most of them outgrow their symptoms, while some have early-onset asthma. Aim of this prospective preliminary study was to apply a metabolomic approach to see whether biochemical-metabolic urinary profiles can have a role in the early identification of the children with asthma. Preschool children with recurrent wheezing were recruited and followed up for 3 years, after which they were classified as cases of transient wheezing or early-onset asthma. A urine sample was collected at recruitment and analyzed using a metabolomic approach based on UPLC mass spectrometry. Among 34 children aged 4.0 ± 1.1 years recruited, at the end of the 3-year follow-up, 16 were classified as having transient wheezing and 16 as cases of early-onset asthma. Through a joint multivariate and univariate statistical analyses, we identified a subset of metabolomic variables that enabled the 2 groups to be clearly distinguished. The model built using the identified variables showed an AUC = 0.99 and an AUC = 0.88 on sevenfold full cross-validation (P = .002). Metabolomic urinary profile can discriminate preschoolers with recurrent wheezing who will outgrow their symptoms from those who have ear...Continue Reading

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Citations

Nov 18, 2018·The Journal of Infectious Diseases·Alessia BarlottaEugenio Baraldi
Mar 26, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Shabarinath NambiarYuben Moodley
Aug 23, 2018·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Philippe Eigenmann
Nov 14, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Philippe Eigenmann
Jun 8, 2018·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Philippe Eigenmann
Feb 26, 2019·Frontiers in Pediatrics·Natalia Hernandez-PachecoCarlos Flores
Nov 28, 2018·Allergy, Asthma & Immunology Research·Yong Ju LeeChang Keun Kim
Sep 19, 2019·Metabolites·Bo L ChawesEugenio Baraldi
Feb 6, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Laura MoschinoEugenio Baraldi
Aug 7, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Philippe Eigenmann
May 8, 2020·Clinical Reviews in Allergy & Immunology·Tesfaye B MershaGurjit K Khurana Hershey
Jan 20, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Philippe Eigenmann
May 1, 2021·Metabolites·Maria Michelle PapamichaelDimitris Tsoukalas
Jul 21, 2021·Molecular Aspects of Medicine·Shengjie XuJoseph Jude

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