When chocolate seeking becomes compulsion: gene-environment interplay

PloS One
Enrico PatronoRossella Ventura

Abstract

Eating disorders appear to be caused by a complex interaction between environmental and genetic factors, and compulsive eating in response to adverse circumstances characterizes many eating disorders. We compared compulsion-like eating in the form of conditioned suppression of palatable food-seeking in adverse situations in stressed C57BL/6J and DBA/2J mice, two well-characterized inbred strains, to determine the influence of gene-environment interplay on this behavioral phenotype. Moreover, we tested the hypothesis that low accumbal D2 receptor (R) availability is a genetic risk factor of food compulsion-like behavior and that environmental conditions that induce compulsive eating alter D2R expression in the striatum. To this end, we measured D1R and D2R expression in the striatum and D1R, D2R and α1R levels in the medial prefrontal cortex, respectively, by western blot. Exposure to environmental conditions induces compulsion-like eating behavior, depending on genetic background. This behavioral pattern is linked to decreased availability of accumbal D2R. Moreover, exposure to certain environmental conditions upregulates D2R and downregulates α1R in the striatum and medial prefrontal cortex, respectively, of compulsive animals...Continue Reading

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Citations

Jan 13, 2018·Nutrients·Marta G Novelle, Carlos Diéguez
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Mar 3, 2020·Neuropharmacology·Matteo Di SegniRossella Ventura
May 4, 2020·Neuroscience and Biobehavioral Reviews·Marjorie C Gondré-LewisKenneth Blum

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