PMID: 11916101Mar 28, 2002Paper

When, for whom and how to use sibutramine?

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
A Astrup, S Toubro

Abstract

Sibutramine is the first of a new generation of weight management drugs, and offers long-term control of weight when used as an adjunct to diet and exercise. This paper considers the criteria set down by the European Union's regulatory agency for its use and how this relates to the information now available on its efficacy, side-effect profile and benefits in different patient groups. The data presented relate to 18-65y olds; its use in other age groups has not been established. The EU licence permits continuous treatment for periods of up to 1 y; the STORM study has now led the US Food and Drug Administration to extend clearance to 2 y. The addition of sibutramine to a regimen of diet, exercise and lifestyle modification results in 3-5 times more patients responding to a weight-reduction programme, ie achieving more than 5% weight maintenance. Sibutramine is indicated for use in obese patients (BMI > 30 kg/m2) and also overweight patients with a BMI > 27 kg/m2 who have additional obesity-related risk factors such as type 2 diabetes or dyslipidaemia.

Citations

Jun 10, 2005·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·William G Haynes, Zoltan Egri
Feb 27, 2007·The American Journal of Medicine·Louis J Aronne
Feb 20, 2007·The American Journal of Cardiology·Michelle Lee, Louis J Aronne
Dec 17, 2004·Obesity Research·Henriette MersebachUlla Feldt-Rasmussen
Jan 21, 2006·Metabolism: Clinical and Experimental·Joseph D ArtissK-L Catherine Jen
Jun 9, 2005·Journal of the American Dietetic Association·Susan B Moyers
Nov 18, 2004·Angiology·S S DaskalopoulouM Elisaf
Nov 28, 2002·Eating and Weight Disorders : EWD·O BoselloC M Rotella

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