When Humans Met Superbugs: Strategies to Tackle Bacterial Resistances to Antibiotics

Biomolecular Concepts
Alicia BravoManuel Espinosa

Abstract

Bacterial resistance to antibiotics poses enormous health and economic burdens to our society, and it is of the essence to explore old and new ways to deal with these problems. Here we review the current status of multi-resistance genes and how they spread among bacteria. We discuss strategies to deal with resistant bacteria, namely the search for new targets and the use of inhibitors of protein-protein interactions, fragment-based methods, or modified antisense RNAs. Finally, we discuss integrated approaches that consider bacterial populations and their niches, as well as the role of global regulators that activate and/or repress the expression of multiple genes in fluctuating environments and, therefore, enable resistant bacteria to colonize new niches. Understanding how the global regulatory circuits work is, probably, the best way to tackle bacterial resistance.

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Citations

Sep 10, 2020·Toxins·Marcin RównickiDariusz Bartosik
Sep 14, 2019·Journal of Microbiological Methods·Fabián Lorenzo-DiazManuel Espinosa
Jun 18, 2021·International Immunopharmacology·Baoyi YinGanzhen Deng
Jul 13, 2021·Frontiers in Molecular Biosciences·Virtu Solano-ColladoAlicia Bravo
Dec 9, 2021·Microbiology and Molecular Biology Reviews : MMBR·M Pilar Garcillán-BarciaManuel Espinosa

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Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

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Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.