When indomethacin fails: additional treatment options for "indomethacin responsive headaches"

Current Pain and Headache Reports
Shuhan Zhu, Brian McGeeney

Abstract

Indomethacin has been used for the treatment of headache disorders since the 1960's, shortly after it was introduced as a treatment for pain and joint swelling in rheumatologic conditions. A subgroup of primary headache disorders, often refractory to other pharmacologic treatment such as triptans and the usual non-steroidal anti-inflammatories, was noted to be exquisitely and absolutely responsive to the analgesic effects of indomethacin. These disorders have been better characterized over the past decade and classified into primary headache disorders of paroxysmal hemicrania (PH) and hemicrania continua (HC). Since the current ICHD-3 beta requires response to indomethacin as a diagnostic criterion, studies on alternative treatments in HC and PH generally occur in patients with intolerance to its gastro-intestinal side effects rather than loss of analgesia effectiveness. More rarely, the development of new headaches have been reported in chronic indomethacin use. In these settings, other classes of medications such as selective cyclooxygenase-2 inhibitors (celecoxib), anti-epileptic agents (topiramate), calcium channel blockers (verapamil, flunarizine), melatonin, and local nerve blocks with anesthetic and steroids have been sh...Continue Reading

References

Feb 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·F CoriaE V de Seijas
Feb 1, 1992·Cephalalgia : an International Journal of Headache·A Kuritzky
Aug 1, 1986·Hypertension·L M RuilopeJ C Romero
Sep 1, 1987·Cephalalgia : an International Journal of Headache·O Sjaastad
Feb 14, 1966·JAMA : the Journal of the American Medical Association·N O Rothermich
Mar 1, 1967·Annals of the Rheumatic Diseases·P L Boardman, F D Hart
Dec 1, 1984·Cephalalgia : an International Journal of Headache·O SjaastadT A Fredriksen
Nov 1, 1981·Archives of Neurology·J L Medina, S Diamond
Jul 1, 1996·Headache·S Evers, I W Husstedt
Jul 26, 2000·Neurology·N T MathewA Fischer
Mar 21, 2002·Cephalalgia : an International Journal of Headache·J A ParejaM Sánchez del Río
Jul 12, 2002·Cephalalgia : an International Journal of Headache·H Mariano Da SilvaJ G Speciali
Aug 9, 2002·Headache·Mario F P Peres, Stephen D Silberstein
Apr 29, 2003·Cephalalgia : an International Journal of Headache·C LisottoG Zanchin
May 1, 1964·Annals of the Rheumatic Diseases·J S PERCYM THOMPSON
Apr 11, 1965·Minerva medica·A ROBECCHIM VIARA
Nov 18, 2003·Cephalalgia : an International Journal of Headache·C LisottoG Zanchin
Aug 28, 2004·Headache·Manjit S MatharuPeter J Goadsby
May 13, 2005·Brain : a Journal of Neurology·M J LevyP J Goadsby
Aug 20, 2005·Headache·Yusuf A Rajabally, Saiju Jacob
Oct 26, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P RossiE Sauli
Feb 14, 2006·Cephalalgia : an International Journal of Headache·M S MatharuM Swash
Feb 14, 2006·Cephalalgia : an International Journal of Headache·T D Rozen
Jul 27, 2006·Headache·Todd D Rozen
Aug 5, 2006·Cephalalgia : an International Journal of Headache·T J SchwedtR S Zimmerman
Jan 11, 2007·Archives of Neurology·Irene FavierJoost Haan
Oct 24, 2007·Clinical Neurology and Neurosurgery·Cecilia CamardaRoberto Monastero
Dec 2, 2008·Journal of the Neurological Sciences·Sanjay PrakashNilima D Shah
Feb 18, 2009·Cephalalgia : an International Journal of Headache·M J MarmuraM Gupta
May 14, 2009·The Journal of Headache and Pain·Roderick C Spears
Jun 6, 2009·Cephalalgia : an International Journal of Headache·M L CuadradoJ Matías-Guiu
Jun 12, 2009·Cephalalgia : an International Journal of Headache·I Garza, F M Cutrer
Jan 27, 2010·Headache·Matthew S RobbinsRichard B Lipton
Jun 3, 2010·The Journal of Headache and Pain·Jesús Porta-EtessamCristina Valencia
Jun 19, 2010·Brain : a Journal of Neurology·Elisabetta Cittadini, Peter J Goadsby
Nov 3, 2010·Cephalalgia : an International Journal of Headache·Krzysztof J NicpońJoanna Jaroszuk-Nicpoń
Jan 1, 2009·BMJ Case Reports·A S Cohen, P J Goadsby
Mar 23, 2012·Cephalalgia : an International Journal of Headache·Ángel L GuerreroRosa Fernández
Mar 24, 2012·Revista brasileira de anestesiologia·Lídia Maria Veras Rocha de MouraNorma Regina Pereira Fleming
May 11, 2012·Headache·Stewart J Tepper

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Citations

Aug 4, 2018·Continuum : Lifelong Learning in Neurology·Mark Burish
Mar 21, 2018·Current Pain and Headache Reports·Alessandro S Zagami
May 29, 2021·Continuum : Lifelong Learning in Neurology·Stephanie J Nahas

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