When Less Is Better: ER Stress and Beta Cell Proliferation

Developmental Cell
Jing YongRandal J Kaufman

Abstract

Pancreatic β cells synthesize and secrete insulin to increase anabolic metabolism in an organism, and insulin synthesis has long been suspected to inhibit β cell replication. Recently in Cell Metabolism, Szabat et al. (2015) present evidence that deletion of Insulin genes alleviates ER stress and promotes mature β cell replication.

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Citations

Aug 11, 2019·Current Diabetes Reports·Ashley A Christensen, Maureen Gannon
Nov 24, 2020·International Wound Journal·Etty Bachar-WikstromJakob D Wikstrom
Apr 14, 2021·Cellular and Molecular Gastroenterology and Hepatology·Xiaoyue CaoHong Bu
Jun 25, 2021·Nature Reviews. Endocrinology·Jing YongRandal J Kaufman

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