When Rhythms Meet the Blues: Circadian Interactions with the Microbiota-Gut-Brain Axis.

Cell Metabolism
Emily M TeichmanJ F Cryan

Abstract

The microbiota-gut-brain axis encompasses a bidirectional mode of communication between the microorganisms residing in our gut, and our brain function and behavior. The composition of the gut microbiota is subject to diurnal variation and is entrained by host circadian rhythms. In turn, a diverse microbiota is essential for optimal regulation of host circadian pathways. Disruption of the cyclical nature of this microbe-host interaction profoundly influences disease pathology and severity. This review aims to summarize current knowledge on this bidirectional relationship. Indeed, the past few years have revealed promising data regarding the relationship between the microbiota-gut-brain axis and circadian rhythms and how they act in concert to influence disease, but further research needs to be done to examine how they coalesce to modulate severity of, and risk for, certain diseases. Moreover, there is a need for a greater understanding of the molecular mechanisms underlying the close relationship between circadian-microbiome-brain interactions.

References

Feb 2, 2002·Science·Matthew R ChapmanScott J Hultgren
Jan 1, 1960·Proceedings of the Society for Experimental Biology and Medicine·F HALBERGJ J BITTNER
Oct 29, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Francesco BenedettiEnrico Smeraldi
Apr 23, 2005·Science·Fred W TurekJoseph Bass
Dec 22, 2006·Nature·Ruth E LeyJeffrey I Gordon
Jan 24, 2007·Journal of Affective Disorders·Greg Murray
Jan 27, 2007·Biochemical and Biophysical Research Communications·Eiko IwahanaShigenobu Shibata
Mar 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kole RoybalColleen A McClung
Nov 7, 2007·Cell Metabolism·Akira KohsakaJoseph Bass
Feb 15, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tami A MartinoMichael J Sole
Dec 2, 2008·Nature·Peter J TurnbaughJeffrey I Gordon
Mar 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Frank A J L ScheerSteven A Shea
May 1, 2009·Nature Reviews. Gastroenterology & Hepatology·Sang H RheeEmeran A Mayer
Dec 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Maren KellerBert Maier
Jul 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yun Kyung LeeSarkis K Mazmanian
Nov 3, 2010·Cell Metabolism·Benedetto GrimaldiPaolo Sassone-Corsi
Dec 21, 2010·Nature Immunology·Kendle M Maslowski, Charles R Mackay
Aug 31, 2011·Proceedings of the National Academy of Sciences of the United States of America·Javier A BravoJohn F Cryan
Jan 5, 2012·PloS One·Thomas BollingerWerner Solbach
Jan 24, 2012·Current Biology : CB·Peter L OliverRussell G Foster
Feb 22, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tsuyoshi MiyaokaJun Horiguchi
Mar 14, 2012·Nature Reviews. Genetics·Ilseung Cho, Martin J Blaser
Mar 15, 2012·Nature Reviews. Neuroscience·Hisham ZiauddeenPaul C Fletcher
Mar 27, 2012·Schizophrenia Research·Emily G SeveranceRobert H Yolken
May 15, 2012·Current Biology : CB·Till RoennebergCéline Vetter
Aug 11, 2012·Progress in Brain Research·Johanna L BarclayHenrik Oster
Aug 14, 2012·Chronobiology International·Gianluigi MazzoccoliAnna Latiano
Jan 15, 2013·Current Opinion in Microbiology·Kelly Schwartz, Blaise R Boles
Feb 9, 2013·Nature Reviews. Immunology·Christoph ScheiermannPaul S Frenette
May 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Amandine EverardPatrice D Cani
May 30, 2013·Proceedings of the National Academy of Sciences of the United States of America·Marina M BelletPaolo Sassone-Corsi

❮ Previous
Next ❯

Citations

Jul 14, 2020·Journal of Pineal Research·Yuying LiJie Yin
Aug 28, 2020·Acta Physiologica·Anna-Marie Finger, Achim Kramer
Jul 3, 2020·Frontiers in Microbiology·Suhelen EganM Pilar Francino
Jul 29, 2020·Nutrients·Jolana Wagner-SkacelSusanne Bengesser
Nov 17, 2020·Environmental Microbiology Reports·Kenneth Timmis
Dec 20, 2020·Cell·Carlos López-Otín, Guido Kroemer
Aug 28, 2020·Current Opinion in Microbiology·Kathy D McCoy, Christina L Ohland
Oct 28, 2020·Nature Reviews. Endocrinology·Faraz BishehsariAli Keshavarzian
Mar 11, 2021·Neuroscience and Biobehavioral Reviews·Joanne S CarpenterIan B Hickie
Mar 17, 2021·Nature Reviews. Neurology·Philippa J KarolyMaxime O Baud
Mar 23, 2021·The ISME Journal·Kankan ZhaoJianming Xu
Apr 4, 2021·Journal of Clinical Medicine·Jorge OjedaPía M Vidal
Jun 15, 2021·Frontiers in Physiology·Tao ChenPeng Chen
Aug 9, 2021·Trends in Molecular Medicine·Paromita SenJohn F Cryan
Aug 28, 2021·Nutrients·Piril Hepsomali, John A Groeger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.