PMID: 9662872Jul 15, 1998Paper

When should your asthmatic patients refill their MDI propelled with chlorofluorocarbons?

Delaware Medical Journal
A G Weinstein

Abstract

The United States Food and Drug Administration has changed its policy regarding product labeling of asthma MDIs. All asthma MDIs propelled by CFCs should be discarded at the discard point labeled on the canister and box. This policy is in transition with inconsistent product information given to patients and physicians. Previously, patients had been educated to replace the canister by observing its floating pattern in water. Now FDA labeling asks users to count the number of actuations. To compare the discard point of sample and prescription-size Serevent (6.5 g and 13 g) and Vanceril 84 DS (5.4 g and 12.2 g) canisters to their floating pattern and total number of actuations in the canisters. Seven canisters each of Serevent 6.5 g and 13 g as well as Vanceril 84 DS 5.4 g and 12.2 g were shaken vigorously prior to actuation. One minute separated each actuation. The floating pattern was observed beginning at 80 percent of the discard point. This was repeated to the last actuation of the canister. The floating pattern (tilt point) indicative to replace the Serevent 6.5 g and 13 g canisters as well as Vanceril 84 DS 5.4 g canister occurred after the discard point was reached. Floating patterns of the 6.5 g and 13 g Serevent inhaler...Continue Reading

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