When Stiffness Matters: Mechanosensing in Heart Development and Disease

Frontiers in Cell and Developmental Biology
Roberto GaetaniElisa Messina

Abstract

During embryonic morphogenesis, the heart undergoes a complex series of cellular phenotypic maturations (e.g., transition of myocytes from proliferative to quiescent or maturation of the contractile apparatus), and this involves stiffening of the extracellular matrix (ECM) acting in concert with morphogenetic signals. The maladaptive remodeling of the myocardium, one of the processes involved in determination of heart failure, also involves mechanical cues, with a progressive stiffening of the tissue that produces cellular mechanical damage, inflammation, and ultimately myocardial fibrosis. The assessment of the biomechanical dependence of the molecular machinery (in myocardial and non-myocardial cells) is therefore essential to contextualize the maturation of the cardiac tissue at early stages and understand its pathologic evolution in aging. Because systems to perform multiscale modeling of cellular and tissue mechanics have been developed, it appears particularly novel to design integrated mechano-molecular models of heart development and disease to be tested in ex vivo reconstituted cells/tissue-mimicking conditions. In the present contribution, we will discuss the latest implication of mechanosensing in heart development a...Continue Reading

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Citations

Aug 26, 2020·Journal of Tissue Engineering and Regenerative Medicine·Ludovic MellyAndrea Banfi
Feb 11, 2021·Biomaterials Science·Harshavardhan BudharajuSwaminathan Sethuraman
Dec 3, 2020·Frontiers in Bioengineering and Biotechnology·Nicolás Andrés SaffiotiDiego Pallarola
Apr 27, 2021·Frontiers in Cell and Developmental Biology·Li LiuYong Xu
Dec 19, 2020·Current Opinion in Pharmacology·Nino ChiricoPieterjan Dierickx
Aug 13, 2021·Frontiers in Cell and Developmental Biology·Yuyu YangYong Xu

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Methods Mentioned

BETA
nuclear translocation
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Software Mentioned

SMD

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