When to stop human chorionic gonadotrophin (hCG) surveillance after treatment with chemotherapy for gestational trophoblastic neoplasia (GTN): A national analysis on over 4,000 patients

Gynecologic Oncology
Kirsty BalachandranM J Seckl

Abstract

To determine the optimal duration of human chorionic gonadotrophin (hCG) surveillance following treatment for low and high risk gestational trophoblastic neoplasia (GTN) and establish whether the current surveillance protocol that recommends life-long hCG monitoring requires revision. A population-based cohort study was undertaken using a national registry, comprising patients from both tertiary trophoblastic disease treatment units in the UK (London and Sheffield). All patients who received chemotherapy for low or high risk GTN in the UK between 1958 and 2014 in London and 1973 and 2015 in Sheffield (n = 4201) were included in the study. Patients with placental site trophoblastic tumours and epithelioid trophoblastic tumours were excluded due to their distinct clinical behavior, treatment and follow-up requirements. The risk of recurrence with time following completion of chemotherapy for low or high risk GTN was measured. The overall risk of relapse in this national cohort of 4201 patients was 4.7% (198/4201) with a median time to recurrence of 117.5 days (range 9 days to 6.54 years). The greatest risk of recurrence occurred in the first year after completing treatment for either low or high risk GTN measuring 72.7% (n = 112)...Continue Reading

References

Jul 1, 1989·British Journal of Obstetrics and Gynaecology·K D BagshaweG J Rustin
Sep 20, 1986·Lancet·K D BagshaweJ Webb
Jan 1, 1986·British Journal of Obstetrics and Gynaecology·E S NewlandsJ Dent
Mar 29, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I A McNeishE S Newlands
Aug 6, 1960·British Medical Journal·K D BAGSHAWE, J M McDONALD
Feb 7, 2004·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·H Y NganUNKNOWN FIGO Committee on Gynecologic Oncology
Aug 3, 2010·Lancet·Michael J SecklRoss S Berkowitz
Aug 27, 2010·American Journal of Obstetrics and Gynecology·John R Lurain
Feb 9, 2012·Chemotherapy Research and Practice·Taymaa MayRoss S Berkowitz
Dec 13, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Constantine AlifrangisMichael J Seckl
Sep 4, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M J SecklUNKNOWN ESMO Guidelines Working Group
Oct 17, 2014·Current Oncology Reports·Fieke E M Froeling, Michael J Seckl
Oct 12, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Hextan Y S NganLeon Massuger

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Citations

Mar 9, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·P SavageM J Seckl
Oct 1, 2020·BJOG : an International Journal of Obstetrics and Gynaecology
Dec 19, 2020·Current Opinion in Obstetrics & Gynecology·James J ClarkMichael J Seckl
Jan 9, 2021·Obstetrics and Gynecology·John T Soper
Mar 3, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ulrika JoneborgChristianne A R Lok
Feb 25, 2021·Best Practice & Research. Clinical Obstetrics & Gynaecology·Antonio BragaRoss S Berkowitz
Mar 21, 2021·Best Practice & Research. Clinical Obstetrics & Gynaecology·Matthew C Winter
Jun 14, 2021·Best Practice & Research. Clinical Obstetrics & Gynaecology·Michael J Seckl, Ehsan Ghorani
Jun 1, 2021·American Journal of Obstetrics and Gynecology·Benjamin B AlbrightLaura J Havrilesky
Nov 5, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Chaokun SheXiaoyun Liu

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