PMID: 8977158Dec 1, 1996Paper

Where are the gates in gap junction channels?

Clinical and Experimental Pharmacology & Physiology
G Dahl

Abstract

1. In the formation and function of gap junction channels two types of gates ought to be discriminated: the docking gate and the channel gates proper. The docking gate is involved in the transformation of a closed hemichannel to a patent gap junction channel. By definition the trigger mechanism for this gate and maybe even the gate itself is contained within the extracellular loops of the gap junction proteins, the connexins. The channel gates proper determine the open and closed states of the complete gap junction channels. 2. Probing the docking gate by mutagenesis of connexins and by synthetic peptides indicates that this gate is the consequence of complex interactions between a large fraction of the amino acids comprising the extracellular loops. Probably both inter- and intra-molecular interactions are involved, and disulfide exchange may be entailed in the stabilization of the open and closed states. 3. Of the various effectors on the channel gate(s) the voltage effects have obtained the most scrutiny to date. The response of gap junction channels and hemichannels is diverse, the various channels respond differently to transjunctional and membrane potential. No equivalent to the S4 segment representing the voltage sensor ...Continue Reading

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Citations

Jun 2, 2010·Pflügers Archiv : European journal of physiology·Ghayda HawatGhayath Baroudi
Oct 6, 1998·The Journal of General Physiology·H B Zhao, J Santos-Sacchi
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Chih-Jen WeiCecilia W Lo
Jul 20, 2002·Respiratory Physiology & Neurobiology·Irene C Solomon, Jay B Dean
Apr 9, 2008·Cell Communication & Adhesion·Gerhard Dahl
Jun 28, 2006·IUBMB Life·Gerhard Dahl, Silviu Locovei
Sep 4, 2014·Frontiers in Physiology·Débora de CarvalhoLuciane H Gargaglioni
Aug 17, 2000·The Journal of Laboratory and Clinical Medicine·N TakahashiM Itoh
Sep 25, 2003·Physiological Reviews·Juan C SaezEric C Beyer
Sep 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jay B DeanIrene C Solomon

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