Where will genetic toxicology testing be in 30 years' time? Summary report of the 25th Industrial Genotoxicity Group Meeting, Royal Society of Medicine, London, November 9, 2011

Mutagenesis
Patricia EllisAndrew Scott

Abstract

A number of influences including legislation, industry and academia have encouraged advances in computational toxicology and high-throughput testing to probe more broadly putative toxicity pathways. The aim of the 25th United Kingdom Mutagen Society (UKEMS) Industrial Genotoxicity Group Annual Meeting 2011 was to explore current and upcoming research tools that may provide new cancer risk estimation approaches and discuss the genotoxicity testing paradigm of the future. The meeting considered whether computer modelling, molecular biology systems and/or adverse outcome pathway approaches can provide more accurate toxicity predictions and whether high-content study data, pluripotent stem cells or new scientific disciplines, such as epigenetics and adductomics, could be integrated into the risk assessment process. With close collaboration between industry, academia and regulators next generation predictive models and high-content tools have the potential to transform genetic toxicology testing in the 21st century.

References

Sep 12, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·David J DixRobert J Kavlock
Feb 24, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kun LuJames A Swenberg
Jun 25, 2010·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel KrewskiLauren Zeise
Dec 16, 2010·Chemical Research in Toxicology·Kun LuJames A Swenberg
Dec 18, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·James A SwenbergThomas B Starr
Feb 15, 2011·Mutation Research·Matthew A ColemanBrinda Mahadevan

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Citations

Jul 30, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jan Vondráček
Jan 7, 2017·Mutagenesis·Benjamin J ReesGeorge E Johnson

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